RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
Modulation of the AC/cAMP/PKA pathway could have the potential to be an effective therapeutic approach for SCD through shear-induced improvements of RBC deformability.
|
31306111 |
2019 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we explored five patients with SCD and multiple RBC alloantibodies who received various forms of immunosuppressive therapy in an attempt to prevent or treat severe DHTRs.
|
30848512 |
2019 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
Forty percent of institutions (33% of non-SCTCs) employ RBC genotyping to evaluate the red cell phenotype for SCD patients.
|
30740798 |
2019 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
The contribution of intracellular hemoglobin (Hb) oxidation to RBC-derived microparticle (MP) formation is poorly defined in sickle cell disease (SCD).
|
30385713 |
2018 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of RBC deformability, sickling and irreversible membrane damage causes abnormal blood rheology, and increases viscosity which contributes to vasoocclusion and other SCD pathophysiology.
|
29660913 |
2018 |
RN7SL263P
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In sickle cell disease (SCD), 'disease severity' associates with increased RBC adhesion to quiescent endothelium, but the impact on activated endothelium is not known.
|
29905377 |
2018 |
RN7SL263P
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Transfusion and Anemia Expertise Initiative developed specific pediatric recommendations regarding RBC transfusion management in critically ill children with sickle cell disease, oncologic disease, and hematopoietic stem cell transplant and recommendations to help guide future research priorities.
|
30161070 |
2018 |
RN7SL263P
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant heterogeneity in RBC adherence response to hypoxia was seen among SCD patients.
|
28387057 |
2017 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conclusion Our study suggests that RBC Duffy expression increases levels of WBCs in SCD patients and that Duffy genotype may not be a potential biomarker for end-organ damage in SCD.
|
26917322 |
2016 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
These actions are relevant to understanding how aromatic aldehydes may affect RBC membrane permeability per se as well as HbS polymerisation and thereby inform design of compounds most efficacious in ameliorating the complications of SCD.
|
24594314 |
2015 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is no universal standard of care for the appropriate selection of RBC products for patients with SCD.
|
21277259 |
2011 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
We postulate that ADRB2 and ADCY6 polymorphisms may influence SCD severity through the mechanism of RBC adhesion.
|
18324973 |
2008 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Lu/BCAM adhesion glycoproteins were first identified as laminin-10/11 erythroid receptors involved in RBC adhesion to endothelium in sickle cell anemia.
|
18948049 |
2008 |
RN7SL263P
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To make these latter points we focus on what is known concerning changes in the RBC proteome in Sickle Cell Disease.
|
18040063 |
2007 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
Red blood cells from patients with sickle cell disease (SS RBC) adhere to laminin and over-express the high-affinity laminin receptor basal cell adhesion molecule/Lutheran protein (B-CAM/LU).
|
14755370 |
2004 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
The usefulness of DNA genotyping for RBC antigens as a tool for the management of multiply-transfused patients with sickle cell disease (SCD) to overcome the limitations of hemagglutination assays was evaluated.
|
11896340 |
2002 |
RN7SL263P
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose that the more deformable the sickle RBC are, the greater their adherence to vascular endothelium, and the more they cause vaso-occlusive crises, RBC deformability and the percentage of dense cells (or ISC) seem to have a predictive value of the frequency and severity of painful crises in sickle cell anemia.
|
3167204 |
1988 |
RN7SL263P
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients with sickle cell disease and alpha thalassemia had higher hemoglobin (Hb) levels, RBC counts, and Hb A2 levels, and lower reticulocyte counts, MCV, MCH, and Hb F levels than those with a normal alpha genotype.
|
2827816 |
1988 |