The interaction of COMT rs737865 and MTHFRC677T was associated with an increased risk of NTDs, especially anencephaly, in a Chinese population with a high prevalence of NTDs.
Effect on risk of anencephaly of gene-nutrient interactions between methylenetetrahydrofolate reductaseC677T polymorphism and maternal folate, vitamin B12 and homocysteine profile.
These preliminary data suggest that the 677C-->T polymorphism of the MTHFR gene is a risk factor for spina bifida and anencephaly that may provide a partial biologic explanation for why folic acid prevents these types of NTD.