Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 AlteredExpression disease BEFREE EA treatment at CV12 reduced the levels of plasma monoamine neurotransmitters 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, dopamine, and norepinephrine; as well as stimulated the expression of GHRL and NPY to alleviate cisplatin-induced anorexia in rats. 31635295 2019
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 Biomarker disease BEFREE Although acute loss of hypothalamic neurons that produce appetite-stimulating neuropeptide Y (Npy) and agouti-related peptide (Agrp) in adult mice or in mice homozygous for the anorexia (<i>anx</i>) mutation causes aphagia, our understanding of the factors that help maintain appetite regulatory circuitry is limited. 28093506 2017
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 Biomarker disease CTD_human Involvement of oxidative stress in the regulation of NPY/CART-mediated appetite control in amphetamine-treated rats. 25825358 2015
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 AlteredExpression disease BEFREE Leptin treatment decreases Arc ceramide levels, with the decrease being important in leptin-induced anorectic actions and down-regulations of NPY and Bsx. 21593415 2011
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 Biomarker disease BEFREE The neuropeptide Y system has proven to be one of the most important regulators of feeding behaviour and energy homeostasis, thus presenting great potential as a therapeutic target for the treatment of disorders such as obesity and at the other extreme, anorexia. 21545413 2011
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 Biomarker disease RGD Based on two replicates of four pooled samples each, both NPY and AgRP mRNA appeared to be elevated in the VMA of anorectic TB rats, while only AgRP exhibited a similar increase in the DMA. 17234300 2007
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 Biomarker disease CTD_human To determine if c-fos or c-jun was involved in the anorectic response of AMPH, infusions of antisense oligonucleotide into the brain were performed at 1 h before daily AMPH treatment in freely moving rats, and the results showed that c-fos or c-jun knockdown could block this anorectic response and restore NPY mRNA level. 16084549 2006
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 Biomarker disease CTD_human To determine if PKCalpha was involved in the anorectic response of AMPH, the infusions of antisense oligonucleotide into the brain were performed 1 h before daily AMPH treatment in freely moving rats, and the results showed that PKCalpha knock down could block the anorectic response and restore NPY mRNA levels in AMPH-treated rats. 16101753 2005
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 Biomarker disease BEFREE Additionally, neuropeptide Y-induced feeding appears to be inhibited in this tumor anorexia model, and this may correlate with increased expression of corticotropin-releasing hormone. 15567470 2004
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 Biomarker disease BEFREE The orexigenic neuropeptides are neuropeptide Y (NPY) and agouti-related peptide (AgRP) and the anorexic neuropeptides are alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine and amphetamine-related transcript (CART). 12468411 2002
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.570 AlteredExpression disease BEFREE We selected three human cancer cell lines [human melanoma (SEKI), human melanoma (G361), and human neuroepithelioma (NAGAI)] that have an ability to develop cancer cachexia syndrome with and without accompanying anorexia and examined the hypothalamic levels of mRNAs for neuropeptide Y (NPY), melanin-concentrating hormone, and orexin. 12094613 2001
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.560 Biomarker disease BEFREE Hypothalamic mechanisms associated with corticotropin-releasing factor-induced anorexia in chicks. 30739813 2019
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.560 Biomarker disease BEFREE Activity-based anorexia activates CRF immunoreactive neurons in female rats. 29574216 2018
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.560 GeneticVariation disease BEFREE Thus, we aimed to test whether age-related variations of CRF effects may also contribute to middle-aged obesity and aging anorexia leading to weight loss of old age groups. 28299639 2017
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.560 GeneticVariation disease BEFREE We hypothesized that urocortin 3 (UCN3) and corticotropin-releasing hormone receptor 2 (CRHR2) are associated with IMCL and subcutaneous fat depth (SFD), because the corticotropin-releasing hormone family of peptides are capable of strong anorectic and thermogenic effects. 17183713 2006
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.560 Biomarker disease CTD_human Corticotropin-releasing factor-1 receptors in the basolateral amygdala mediate stress-induced anorexia. 16420149 2005
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.560 AlteredExpression disease BEFREE Additionally, neuropeptide Y-induced feeding appears to be inhibited in this tumor anorexia model, and this may correlate with increased expression of corticotropin-releasing hormone. 15567470 2004
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.560 Biomarker disease RGD We determined if increased insulin within the brain potentiates the anorexic effects of intraventricular CRH. 12429558 2002
Entrez Id: 1392
Gene Symbol: CRH
CRH
0.560 AlteredExpression disease BEFREE The present results also raise the possibility that leptin reduces food intake and b.w. at least partially due to the enhancement of the anorectic effect of CRH via increased PVN CRH expression and/or VMH CRHR-2 expression. 10223285 1999
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.540 Biomarker disease BEFREE CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively. 30979915 2019
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.540 GeneticVariation disease BEFREE However, CRF(2) deletion abolished the prolonged phase of restraint-induced anorexia. 17953621 2007
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.540 Biomarker disease CTD_human Thus, DIO rats showed signs of a preexisting, heritable deficit in the maintenance of postmeal satiety and a reduced sensitivity to anorectic CRF(2) agonist stimulation. 17627984 2007
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.540 Biomarker disease BEFREE We hypothesized that urocortin 3 (UCN3) and corticotropin-releasing hormone receptor 2 (CRHR2) are associated with IMCL and subcutaneous fat depth (SFD), because the corticotropin-releasing hormone family of peptides are capable of strong anorectic and thermogenic effects. 17183713 2006
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.540 Biomarker disease RGD Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat. 17050037 2006
Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
0.540 AlteredExpression disease BEFREE The present results also raise the possibility that leptin reduces food intake and b.w. at least partially due to the enhancement of the anorectic effect of CRH via increased PVN CRH expression and/or VMH CRHR-2 expression. 10223285 1999