We showed that in human coal pneumoconiosis autopsy specimens, Sonic Hedgehog (SHH) and the Glioma-associated oncogene homolog transcription factors family (GLI) 1 proteins were up-regulated, whereas Patch-1 (PTC) was down-regulated.
The present study is the first to have demonstrated an association between CYBA (rs7195830) polymorphism and the risk of developing CWP in subjects belong to the Han ethnic group in China and provides further clues for research into the pathogenesis of CWP.
Univariate and multivariate analyses suggested that CWP grade, initial exposure time, exposure time inyears, and CWP onset agewereall associated with altered levels of Bcl-2, Caspase-3 and Caspase-8.
Univariate and multivariate analyses suggested that CWP grade, initial exposure time, exposure time inyears, and CWP onset agewereall associated with altered levels of Bcl-2, Caspase-3 and Caspase-8.
LncRNA-ATB was positively associated with transforming growth factor-β1 (TGF-β1) (r = 0.30, p = 0.003) and negative correlated with vital capacity (VC) (r = -0.18, p = 0.033) and forced vital capacity (FVC) (r = -0.18, p = 0.046) in CWP patients.
Our results indicated that rs2067051 in the H19 gene is correlated with a deceased risk of CWP in a Chinese population, which may be a potential genetic marker for prevention and intervention of CWP.
Our results indicate that three functional SNPs (MMP-7rs10502001, OPN rs11728697 and OPN rs1126772) are associated with an increased risk of CWP in a Chinese population.
We investigated the association of three functional polymorphisms in MMP gene promoters (MMP1rs1799750, MMP2 rs2285053 and MMP3 rs522616) with the risk of CWP.
We investigated the association of three functional polymorphisms in MMP gene promoters (MMP1 rs1799750, MMP2rs2285053 and MMP3 rs522616) with the risk of CWP.
The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of IL-17A and CWP in a Chinese population.
Our results indicate that three functional SNPs (MMP-7 rs10502001, OPNrs11728697 and OPNrs1126772) are associated with an increased risk of CWP in a Chinese population.
These findings indicate that the MMP3rs522616 polymorphism may contribute to the etiology of CWP in the Chinese population and MMP3 might be a potential diagnostic biomarker for CWP, additional independent studies are warranted to validate our findings in different populations as well as in a larger series.
This is the first report showing an association between the MUC5Brs2672794 polymorphism and CWP, and our results suggest that MUC5Brs2672794 CC genotype could increase the risk of CWP.
The SELErs5368 CT genotype was associated with a significantly increased risk of CWP (OR = 1.28, 95% CI = 1.02-1.60, P = 0.03) relative to the CC genotype.
This is the first report showing an association between the NLRP3rs1539019 polymorphism and CWP, and suggests that this polymorphism may confer increased risk for the development of the disease.
Furthermore, five HSP haplotypes of the HSP70 genes (namely GAT, GAC, GGT, CAC and CGT) were examined and the frequencies of haplotypes GAT and GGT were significantly higher in the CWP than in the control group.
Furthermore, five HSP haplotypes of the HSP70 genes (namely GAT, GAC, GGT, CAC and CGT) were examined and the frequencies of haplotypes GAT and GGT were significantly higher in the CWP than in the control group.