Together, the results indicate that plasma BDNF levels are related to amygdala circuit functioning in humans, particularly during anxiety, and these individual differences may relate to drinking behaviors.
Our results showed that both PD patients and normal controls with the BDNF Met/Met genotype had significantly higher total and difficulty describing feelings(DDF) subdimension scores on the TAS-20 than those with the Val/Val genotype.The patients with the BDNF Met/Met genotype were more severity of anticipatory anxiety than patients with Val/Val genotype.
The presence of PSA was determined using the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS), and the effects of BDNF methylation status and polymorphisms on PSA status were assessed with multivariate logistic regression models.
Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations.
Interactive genetic association with anxiety was observed such that effects of 5-HTTLPR depended on the BDNFVal66Met polymorphism (rs6265 variant), with higher anxiety scores in short and Met carriers compared to the other allelic groups.
The aim of the present case-control study was to explore the association between BDNFVal66Met (rs6265) polymorphism and generalized anxiety disorder in Mexican individuals, and whether this polymorphism plays a role in the symptomatology of anxiety.A total of 212 subjects were included in the study.
Results indicated that β-alanine ingestion in both young and older rats was effective in attenuating anxiety and augmenting BDNF expression in the hippocampus.
Our aim was to investigate the effects of ETS during the early postnatal period on locomotor activity and anxiety and in the presynaptic proteins and brain-derived neurotrophic factor (BDNF) in distinct brain regions.
The aim of this study was to evaluate salivary cortisol and plasma brain-derived neurotrophic factor (BDNF) in people with PD, to compare them with healthy controls and to associate them with levels of anxiety and depression.
In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats.
No gene-by-environment interaction of BDNF <i>Val66Met</i> polymorphism and childhood maltreatment on anxiety sensitivity in a mixed race adolescent sample.
Furthermore, a stepwise multiple regression analysis of serum BDNF levels as a dependent variable with related factors showed that in heroin users, Alcohol Use Disorder Identification Test score, anxiety and RT score were found as independent contributors to serum BDNF levels.
Multivariate analysis of covariance (MANCOVA) revealed a significant main effect on both groups for the levels of serum cytokine, chemokine, and BDNF, an effect that was independent of severities of depression and anxiety [Pillai's Trace V = 0.371, F (11, 70) = 3.756, p < 0.001, hp<sup>2</sup> = 0.187].
Ovariectomy caused anxiety and declined the physical power as well as BDNF and SOD levels. d-gal administration in ovariectomized mice exacerbated these deleterious effects.
A single-nucleotide polymorphism in the BDNF gene (BDNFVal66Met), associated with depression and anxiety, has been proposed as a genetic risk factor for CVD.
Inhibition of stress-induced elevations in brain-derived neurotrophic factor (BDNF) or its primary receptor tyrosine-related kinase B (TrkB) within the reward pathway may modulate vulnerability to anxiety and mood disorders.
The normalized change in BDNF levels was inversely correlated with BSI-18 anxiety scores at both the pre-retreat (<i>r</i> = 0.40, <i>p</i> < 0.05) and post-retreat (<i>r</i> = 0.52, <i>p</i> < 0.005) such that those with greater anxiety scores tended to exhibit smaller pre- to post-retreat increases in plasma BDNF levels.