Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Ninety-two-kilodalton type IV collagenase (MMP-9) is present in aortic aneurysms and may be important to the pathogenesis of this disease. 7627707 1995
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease CTD_human PGE2 and MMP-9 are elevated in aortic aneurysms. 10231640 1999
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 GeneticVariation disease LHGDN A single nucleotide polymorphism in the matrix metalloproteinase 9 gene (-8202A/G) is associated with thoracic aortic aneurysms and thoracic aortic dissection. 16678588 2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE The present study extends that observation and documents asymmetric aneurysm development in the TAA wall, with increased anterior wall growth in correlation to increased MMP-9 production. 16476613 2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease LHGDN The present study extends that observation and documents asymmetric aneurysm development in the TAA wall, with increased anterior wall growth in correlation to increased MMP-9 production. 16476613 2006
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Furthermore, the combination of local periaortic leptin and systemic angiotensin II administration augmented medial MMP-9 synthesis and aortic aneurysm size. 23220275 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE AAA SMCs demonstrated twofold greater expression of MMP-2 messenger (m)RNA (P < .05) and 7.3-fold greater MMP-9 expression (P < .01) than NAA-SMCs. 24080131 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE Matrix metalloproteinases (MMPs), especially MMP-9, is implicated in the development of aortic aneurysm, but the effective MMP inhibitors are far from development. 27663582 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE The objectives of this study were to identify interrelations between matrix metalloproteinase-2 (MMP2)/MMP9 levels and clinical variables in patients with aortic root/ascending aortic aneurysms and to describe comorbidities as possible biasing factors in the widely discussed correlation of serum MMP levels and aortic diameter. 27659153 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Expression levels of ADAMTS‑7 and matrix metalloproteinase‑9 were significantly increased in the AA group, as detected by immunohistochemistry (P<0.05). 28849199 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE UCP-2 knockout up-regulated the MMP2 and MMP9 expression in aortic aneurysm. 28683125 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 GeneticVariation disease BEFREE Several studies of gene polymorphisms support MMP-9 for TAA and MMP-3 for AAA as potentially important factors. 28413030 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE Moreover, MMP9 levels were significantly higher in TAA group than those in AAA group in the total comparison, and this discrepancy was also found in the non-diabetes, non-hyperlipidemia and aortic diameter ≥ 5.5 cm subgroup analysis. 30373522 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 GeneticVariation disease BEFREE The objective of this study was to evaluate the interactions between TLR4 and MMP9 polymorphisms in the risk of aortic aneurysm (AA) and its subtypes. 30922233 2019