There is a decrease in the percentage of AA, associated with an increase of PLA<sub>2</sub>, COX2/TXA2R, CYP450 4A, and 5-LOX which leads to a greater synthesis of PGE<sub>2</sub> than of 6-keto-PGF<sub>1α</sub>, thus contributing to the formation of the aortic aneurysm.
These data link the 5-LO pathway to hyperlipidemia-dependent inflammation of the arterial wall and to pathogenesis of aortic aneurysms through a potential chemokine intermediary route.