Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE In a randomly sampled cross-sectional study of 985 South Asian, Chinese, and European Canadians, three common isoforms of ApoE (E2, E3 and E4), plasma lipid concentrations and atherosclerosis of the carotid artery were measured. 18656198 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE The NOS3 G894T polymorphic variant also correlated with atherosclerosis, an association probably mediated by the traditional risk factors for CVD. 29948131 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Among 1677 nondemented ARIC (Atherosclerosis Risk in Communities) participants (mean age=76±5 years; 40% men; 26% black) with 3-Tesla MRI scans at the fifth examination (2011-2013), we fit multinomial logistic regression models to quantify relationships of brain volumes (Alzheimer disease signature regions, total gray matter, frontal gray matter, and white matter hyperintensity volumes), infarct frequencies (lacunar, nonlacunar, and total), and apolipoprotein E (number of ε4 alleles) with CMB location (none, deep/mixed, or strictly lobar CMBs). 29018129 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis. 7762561 1995
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 GeneticVariation disease BEFREE Previous studies suggest that klotho gene polymorphisms may be associated with atherosclerosis, but did not assess the relationship between klotho gene polymorphisms and atherosclerosis parameters such as carotid artery intima-media thickness (IMT). 20345435 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been implicated in the pathogenesis of native atherosclerosis. 12819869 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Apolipoprotein E gene polymorphism in renal transplant recipients: effects on lipid metabolism, atherosclerosis and allograft function. 15142050 2004
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE In this study, we evaluated the effects of complete IL-25 deficiency or of a temporal IL-25 blockade on atherosclerosis development in apolipoprotein E-deficient (<i>Apoe</i><sup>-/-</sup>) mice. 29572351 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE We recently described that apolipoprotein E (ApoE) deficient mice with a mutation in the fibrillin-1 (Fbn1) gene (ApoE<sup>-/-</sup>Fbn1<sup>C1039G+/-</sup>) develop accelerated atherosclerosis, plaque rupture, myocardial infarction, cerebral hypoxia and sudden death. 31085310 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Clinical and autoptical studies have suggested a predisposing role of the allele E4 of apolipoprotein E (apoE) in the development of atherosclerosis and cardiovascular disease. 9012642 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE The molecular polymorphism displayed by apolipoprotein E (apoE, protein; APOE, gene) has been listed as a risk factor for susceptibility to various disorders, such as those associated with lipid metabolism and arteriosclerosis. 14763609 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Beyond the known influence of ApoE polymorphisms on serum lipid profile, the pathogenesis of atherosclerosis, and the development of neurodegenerative disorders, ApoE also has a major role in the pathogenesis and progression of a variety of renal diseases, as well as in the atherosclerotic complications associated with them. 14750087 2004
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE These findings support the proposal that common genetic variations in the eNOS gene contribute to atherosclerosis susceptibility, presumably by effects on endothelial NO availability. 15007011 2004
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE In conclusion, the homozygous NOS III variant (GG) status does not seem to interact additively with the ACE homozygous DD genotype in determining flow-mediated vasodilation in individuals with established atherosclerosis and pre-existent endothelial dysfunction. 14989558 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE On the other hand, apolipoprotein E3/2 heterozygosity may have a protective effect on the development of early atherosclerosis. 6882285 1983
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE The objective of this study was to investigate the influence of the APOE promoter (-491 A/T, -427 T/C and -219 G/T) and coding region (APOE epsilon2/epsilon3/epsilon4) polymorphisms in atherosclerosis disease by association and linkage disequilibrium analyses. 18219091 2008
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE It was the objective of this study to investigate the relation between nitric oxide synthase (NOS3) gene polymorphisms, vascular inflammation, endothelial function, and atherosclerosis. 17003932 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic <i>APOE*3-Leiden</i> (<i>E3L</i>) mice. 29401645 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE These findings support extension of the importance of the apoE4 allele beyond atherosclerosis and Alzheimer's disease to calcific AS. 14530190 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE In the present study, we analyzed the G894T polymorphism of the eNOS gene in groups of individuals diagnosed with atherosclerosis and in a control group. 28481400 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study. 12774036 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Risk for arteriosclerosis is modulated by the apolipoprotein E (apoE) allele. 11096027 2000
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease. 15494775 2004
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE In Gbeta3 polymorphism, the 825T allele carriers had a significantly lower body mass index while in eNOS polymorphism there were no links between genotypes, renal function and atherosclerosis risk factors. 12424427 2002
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Since nuclear factor-κB (NF-κB) is a central regulator of inflammatory processes, we hypothesized that chronically enhanced hepatic NF-κB activation, through hepatocyte-specific expression of IκB kinase-β (IKKβ) (LIKK), will aggravate atherosclerosis development in APOE*3-Leiden (E3L) mice. 21798539 2012