Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1462
Gene Symbol: VCAN
VCAN
0.260 Biomarker disease BEFREE Proteoglycan 4 (Prg4) has a high structural similarity with the established atherosclerosis-modulating proteoglycan versican, but its role in atherogenesis is still unknown. 29772480 2018
Entrez Id: 1462
Gene Symbol: VCAN
VCAN
0.260 Biomarker disease BEFREE The reduction of ADAMTS-5 was accompanied by accumulation of biglycan and versican, the major lipoprotein-binding proteoglycans, in atherosclerosis. 22493487 2012
Entrez Id: 1462
Gene Symbol: VCAN
VCAN
0.260 Biomarker disease BEFREE The ability of the ADAMTS proteases to degrade versican, the primary proteoglycan in the vasculature, is thought to be central to any hypothesized role for the proteases in atherosclerosis. 20652528 2010
Entrez Id: 1462
Gene Symbol: VCAN
VCAN
0.260 Biomarker disease BEFREE The physiology of versican and its role in the progression of diseases such as atherosclerosis, cancer, and central nervous system injury are discussed. 18661349 2008
Entrez Id: 1462
Gene Symbol: VCAN
VCAN
0.260 Biomarker disease BEFREE Analysis of extracellular matrix composition revealed prominent accumulation of versican, a presumed proatherogenic matrix component abundant in human lesions but almost absent in the widely-used C57BL/6 murine atherosclerosis model. 18818413 2008
Entrez Id: 1462
Gene Symbol: VCAN
VCAN
0.260 Biomarker disease BEFREE Versican is also prominent in advanced lesions of atherosclerosis, at the borders of lipid-filled necrotic cores as well as at the plaque-thrombus interface, suggesting roles in lipid accumulation, inflammation, and thrombosis. 15142969 2004
Entrez Id: 1462
Gene Symbol: VCAN
VCAN
0.260 Biomarker disease RGD The large chondroitin sulfate proteoglycan versican is synthesized by vascular smooth muscle cells (SMCs), accumulates during human atherosclerosis and restenosis, and has been shown to bind LDLs. 10397680 1999