Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.070 AlteredExpression disease BEFREE In summary, hAR expression amplifies impaired atherosclerosis regression in diabetic mice, likely by interfering with the expected reduction in plaque macrophage inflammation. 29891593 2018
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.070 Biomarker disease BEFREE Aldose reductase (AR; gene AKR1B1) is the rate-limiting enzyme of the polyol pathway and has been associated with diabetes and atherosclerosis. 26873505 2016
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.070 AlteredExpression disease BEFREE In conclusion, our data demonstrate a novel mechanism by which glucose flux via AR triggers activation, acetylation, and prolonged expression of Egr-1 leading to proinflammatory and prothrombotic responses in diabetic atherosclerosis. 24186862 2014
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.070 AlteredExpression disease BEFREE Although in some settings AR expression might reduce levels of toxic aldehydes, transgenic expression of this enzyme within the artery wall leads to greater atherosclerosis. 21636809 2011
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.070 Biomarker disease BEFREE In contrast, a recent report suggests that genetic ablation of AR increased atherosclerosis and increased hydroxynonenal in arteries. 20466987 2010
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.070 AlteredExpression disease BEFREE We discovered AR expression in foam cells by gene chip screening and hypothesized that it may be relevant in atherosclerosis. 18451330 2008
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.070 Biomarker disease BEFREE Inhibitors of AR or other enzymes that mediate glucose toxicity could be useful in the treatment of diabetic atherosclerosis. 16127462 2005