| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | It seems that this master regulator triggers either some hyperglycaemia-induced effects on the endothelial function, or the expression of certain microRNAs (in particular miR-126, -21 and miR-146a-5p) involved in favouring atherosclerosis. | 31722564 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our findings indicate that exosomal miR-146a derived from oxLDL-treated macrophages promotes NETs formation via inducing oxidative stress, which might provide a novel scientific basis for the understanding of AS progression. | 31416388 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | However, it is uncertain if LPS, a major inducer of inflammation, affects CXCL16 expression in endothelial cells and whether miR-146a, a negative regulator of atherosclerosis, participates in this process. | 30710793 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Here we evaluated the ability of miR-146a expression in the hematopoietic component to regulate atherosclerosis in low-density lipoprotein receptor-null mice (Ldlr-/-). | 29902229 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | EV-derived miRNAs from atherogenic macrophages, in particular miR-146a, may accelerate the development of atherosclerosis by decreasing cell migration and promoting macrophage entrapment in the vessel wall. | 28882869 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Overall, the results of the present study suggested that CXCL16 may regulate the TRL4/NF‑κB/CXCL16 signaling pathway, and that miR‑146a and miR‑146b may negatively regulate CXCL16 via this pathway in atherosclerosis in vivo. | 30015963 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a. | 28637783 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | The results support the concept that miR-146a may be a novel regulatory factor in Th1 differentiation and a new therapeutic target for AS and ACS. | 20195282 | 2010 |