Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Our findings show that macrophage NCOR1 blocks the pro-atherogenic functions of PPARγ in atherosclerosis and suggest that stabilizing the NCOR1-PPARγ binding could be a promising strategy to block the pro-atherogenic functions of plaque macrophages and lesion progression in atherosclerotic patients. 31529020 2020
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Aortic wall shows histopathological evidence of atherosclerosis in obesity group which is more evident in atherosclerotic group, and milder changes upon receiving PPARγ agonist. 30612469 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE In addition, loss of function of PPARγ enhances cardiovascular events and atherosclerosis in the vascular endothelium. 31055770 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Metabolic reprogramming in atherosclerosis: Opposed interplay between the canonical WNT/β-catenin pathway and PPARγ. 31153873 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor gamma (PPAR<sub>γ</sub>) has recently been identified as an attractive target for atherosclerosis intervention. 31099308 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE PPARγ and PPARα belong to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. 30697628 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE <b>Results:</b> Our results indicated that the protein levels of HMGB1, TLR4, and pro-inflammatory cytokines including IL-1β, TNF-α were elevated with the development of atherosclerosis in CUMS mice, while the expressions of PPARγ, LXRα, and ABCA1 declined. 30881312 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE On the whole, these results demonstrate that quercetin prevents the development of AS in apoE‑/‑ mice by regulating the expression of PCSK9, CD36, PPARγ, LXRα and ABCA1. 31524223 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Recent advances on the emerging role of CD36 and GHRP hexarelin in regulating PPARγ downstream actions with benefits on atherosclerosis, hepatic cholesterol biosynthesis and fat mitochondrial biogenesis are summarized here. 29883404 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE In addition, PPARγ antagonist GW9662 co-administration mostly blocked these effects, suggesting the important role of PPARγ pathways in mediating 20(S)-Rg3 effects in macrophage polarization and atherosclerosis progression. 29867472 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE It is of great interest to understand the stereochemical selectivity of 20(R/S)-Rg3 and explore whether differential PPARγ activation by Rg3 stereoisomers, if it exists, could lead to differential physiological outcome and therapeutic effects in diabetic atherosclerosis. 29566305 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Previously, we reported that selective deletion of PPARγ (peroxisome proliferator-activated receptor γ) in vascular smooth muscle cells resulted in concurrent loss of PVAT and enhanced atherosclerosis in mice. 29954752 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE These results suggested that AGP plays a significant role in the initiation/progression of diabetes-related atherosclerosis through PPARγ activation. 29355589 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. 29628981 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE According to the results of a preliminary study, it was hypothesized that the effects of adiponectin (APN) on the improvement of atherosclerosis may be associated with adipocyte differentiation and peroxisome proliferator‑activated receptor γ (PPARγ). 29115433 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE The wide spectrum of PPAR-γ activation effects may be beneficial for treatment of various cardiovascular conditions as atherosclerosis, hypertension and aortic aneurysm, including surgical interventions. 27855608 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Activation of macrophage ABCA1/G1 expression and cholesterol efflux is believed one of the mechanisms by which PPARγ inhibits atherosclerosis. 27890613 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE This study highlights the functional dichotomy of intracellular versus extracellular NAMPT, and unveils a critical role for the iNAMPT-peroxisome proliferator-activated receptor γ axis in atherosclerosis. 28408371 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE And the underlying mechanism of OA on atherosclerosis may involve in lipid metabolism genes: PPARγ, AdipoR1, and AdipoR2. 28338883 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE In cardiovascular disease, PPARγ inhibits atherosclerosis but TR4 enhances atherosclerosis through increasing foam cell formation. 28527578 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE The mechanisms by which endothelial PPAR-γ regulates inflammatory responses and protects against atherosclerosis remain unclear. 26566726 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor-γ (PPARγ), liver X receptor-α (LXRα), and PPARγ co-activator-1α (PGC-1α) are nuclear factors that regulate lipid metabolism and inflammation implicated in atherosclerosis. 27016616 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Peroxisome proliferator-activated receptor gamma (PPARG) is a transcription factor involved in atherosclerosis and related diseases. 27264718 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE In the atherosclerosis mice, GQ-177 inhibited atherosclerotic lesion progression, increased plasma HDL and mRNA levels of PPARγ and ATP-binding cassette A1 in atherosclerotic lesions. 26706782 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Notably, additional Tg(PPAR-γ) or pharmacological activation of PPAR-γ effectively prevented Tg(DNMT1)-induced proinflammatory cytokine production in macrophages and AS development in the mouse model. 27530451 2016