| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.170 | GeneticVariation | disease | BEFREE | HLA-DRB1 typing and PTPN22 allelic discrimination could distinguish between patients with UA, patients with early RA, and the general population in Argentina. | 30306282 | 2019 | ||||
|
0.170 | Biomarker | disease | BEFREE | Ptpn22 promoted host antiviral responses and was critical for TLR agonist-induced, type 1 IFN-dependent suppression of inflammation in colitis and arthritis. | 23871208 | 2013 | ||||
|
0.170 | Biomarker | disease | BEFREE | To evaluate the predictive value of TNFRII 196R, PTPN22 1858T and HLA-shared epitope (SE) alleles, RFs and anti-citrullinated protein antibodies (ACPAs) for RA diagnosis in a cohort of patients with very early arthritis. | 18535030 | 2008 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | A total of 667 RA patients and 286 controls were genotyped for 13 PTPN22 single nucleotide polymorphisms (SNPs) by allele-specific kinetic polymerase chain reaction. rs3789604 was genotyped in an additional 410 RA and 270 UA patients participating in the Leiden early arthritis inception cohort. | 17135225 | 2007 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients. | 17341507 | 2007 | ||||
|
0.170 | GeneticVariation | disease | LHGDN | Additional analyses identified two SNPs on a single common haplotype that are associated with RA independent of R620W, suggesting that R620W and at least one additional variant in the PTPN22 gene region influence RA susceptibility. | 16175503 | 2005 | ||||
|
0.170 | GeneticVariation | disease | LHGDN | The transmission disequilibrium test of the PTPN22-620W allele revealed linkage and association for RF+ RA (61% of transmission, P = 0.037). | 16277672 | 2005 | ||||
|
0.170 | Biomarker | disease | HPO |