|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The allele-positivity rate of DRB1*04: 05 was also higher in the ICI-induced inflammatory arthritis group.
|
30508191 |
2019 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Frequency of human leukocyte antigens class II-DR alleles (HLA-DRB1) in Argentinian patients with early arthritis.
|
30306282 |
2019 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
DRB1∗04 molecules modulate the DQ8-restricted response and determine the outcome of arthritis in mice carrying DR4/DQ8 haplotype.
|
25541434 |
2015 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and associates with HLA-DRB1*04.
|
26844284 |
2015 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
|
23180817 |
2013 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Antigen presentation by B cells leads to a sex-specific immune response in DRB1*0401 mice suggesting a role of B cells and HLA-DR in rendering susceptibility to develop arthritis in females.
|
21665435 |
2011 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The sub-GRS was more strongly associated than any single SNP effect for 5 subphenotypes (the above plus hematologic disorder and oral ulcers), while single loci are more significantly associated with renal disease (HLA-DRB1, OR = 1.37, 95% CI 1.14-1.64) and arthritis (ITGAM, OR = 0.72, 95% CI 0.59-0.88).
|
21379322 |
2011 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HLA class II allele DRB1*0401 is associated with predisposition to Rheumatoid Arthritis in humans as well as collagen-induced arthritis in mice.
|
20061120 |
2010 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Hormonal replacement therapy may reduce the risk for RA in women with early arthritis who carry HLA-DRB1 *01 and/or *04 alleles by protecting against the production of anti-CCP: results from the ESPOIR cohort.
|
19740903 |
2010 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
LHGDN |
Associations of erosive arthritis with anti-cyclic citrullinated peptide antibodies and MHC Class II alleles in systemic lupus erythematosus.
|
18085741 |
2008 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
LHGDN |
Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis.
|
18240242 |
2008 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In double-Tg mice, the DRB1*0401 gene contributes to the development of collagen-induced arthritis, whereas DRB1*0402 prevents the disease.
|
18684978 |
2008 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Patients with PsA carrying both HLA-Cw6 and HLA-DRB1*07 alleles have a less severe course of arthritis.
|
17223660 |
2007 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In 2 cohorts of anti-citrullinated peptide 2-positive patients with RA, one from a study of recent-onset arthritis (n = 206) and the other from a treatment strategy study (n = 141), serum antibodies against a citrullinated peptide derived from vimentin (cVim) and antibodies against a citrullinated fibrinogen peptide (cFibr) were determined by enzyme-linked immunosorbent assay.HLA-DRB1 genotyping was performed.
|
18050209 |
2007 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, when stratified by antibiotic response, the frequencies of DRB1 alleles in the 71 patients with antibiotic-refractory arthritis differed significantly from those in the 50 antibiotic-responsive patients (log likelihood test, P = 0.006; exact test, P = 0.008; effect size, Wn = 0.38).
|
16585267 |
2006 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
We conclude that, in Taiwan, HLA-DRB1*0405 is associated with the development of polyarthritis and oligoarthritis in children, and HLA-DRB1*1502 is associated with the development of systemic arthritis.
|
15265024 |
2004 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In vivo depletion of DRB1*0402 did not lead to induction of collagen-induced arthritis in transgenic mice.
|
14530370 |
2003 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
LHGDN |
In addition, DRB1*0402 protects B10.RQB3 mice against developing arthritis with bovine type II collagen.
|
14530370 |
2003 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Additionally, persistent disease was predicted by the presence of DRB1*08, and joint erosions were predicted by symmetric arthritis and DRB1*08 and HLA-B27 in combination.
|
12563700 |
2003 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The magnitude of OspA(163-175) binding correlated well with the frequencies of the DRB1 alleles in patients with treatment-resistant arthritis, but the binding of hLFA-1alpha(L330-342) showed only an association with the DRB*04 alleles.
|
12571864 |
2003 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Treatment-resistant Lyme arthritis patients' T cells, cloned based on their ability to bind OspA165-173-loaded HLA-DRB1*0401 tetramers, respond to OspA and hLFA1alpha with a different cytokine profile, suggesting that hLFA1alpha acts as a partial agonist with a potential role in the perpetuation of joint inflammation.
|
12118172 |
2002 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Immunizing mice transgenic for the human HLA-DRB1*0101 immune response gene with CII elicits an arthritis (collagen-induced arthritis [CIA]) that resembles rheumatoid arthritis.
|
12483744 |
2002 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The majority of patients with treatment-resistant Lyme arthritis have HLA-DRB1*0401 or related alleles, and the severity and duration of their arthritis correlate with cellular and humoral immune responses to outer-surface protein A OspA) of the spirochete.
|
11334491 |
2001 |
|
HLA-DRB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
DRB1 alleles encoding a DERAA motif in their third hypervariable region provided a strong dominant protection against RA among DQ5-positive individuals and decreased arthritis activity among DQ3-positive patients.
|
11257148 |
2001 |
|
HLA-DRB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
The strongest HLA association was with HLA-DRB1*0401 for FS [OR 27.9 (10.3-75.5), P = 10(-13)], and LGL with arthritis [OR 35.4 (9.6-131.3), P = 10(-10)].
|
10817772 |
2000 |