| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | disease | BEFREE | Mice with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80, given every second day. | 29375132 | 2019 | ||||
|
0.090 | Biomarker | disease | BEFREE | Thus it can be suggested that combined administration of TNFR-1 and TNFR-2 antibody has a beneficial effect against the severity of S. aureus induced arthritis. | 29339199 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | In the CIA model, we demonstrated that administration of the TNFRII agonist EHD2-sc-mTNF<sub>R</sub><sub>2</sub> led to the expansion of both CD4+ and CD8+ Treg cells in vivo and induced antiinflammatory responses that alleviated arthritis. | 29342501 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | Reduction in arthritis index was noticed in infected mice treated with both MMP-2 inhibitor and TNFR2 antibody. | 29218573 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | Here, we investigate the mesenchymal-specific role of Tnfr2 in the TnfΔARE mouse model of SpA in arthritis and heart valve stenosis comorbidity by cell-specific, Col6a1-cre-driven gene targeting. | 29618659 | 2018 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | However, the course of arthritis was marked by elevation of Treg frequency and a dramatic increase in expression of TNFR2. | 21346237 | 2011 | ||||
|
0.090 | Biomarker | disease | LHGDN | Soluble tumour necrosis factor receptors sTNFR1 and sTNFR2 are produced at sites of inflammation and are markers of arthritis activity in Behçet's disease. | 18415772 | 2008 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Clinical and histologic progression of arthritis in the tmTNFalpha-transgenic/TNFalpha-KO mice was reduced by treatment with dexamethasone or with the p55 or p75 sTNFR (69% and 63% reduction in total histologic score, respectively). | 16947419 | 2006 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | To assess the association between the tumour necrosis factor receptor 2 (TNFR2) 196 M/R single-nucleotide polymorphism and rheumatoid arthritis (RA) severity by taking advantage of the extremes of phenotype that exist in arthritis. | 15252214 | 2004 |