Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 Biomarker disease BEFREE The following information was recorded in web-based case report forms: demographic, clinical and radiographic data; physical examination findings, including tender and swollen joint counts (TJC and SJC); nail and skin involvement; Disease Activity Score-28 for Rheumatoid Arthritis with Erythrocyte Sedimentation Rate (DAS 28-ESR); Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); Maastricht Ankylosing Spondylitis Enthesitis Score (MASES); Psoriasis Area Severity Index (PASI); Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI-s); Health Assessment Questionnaire (HAQ); Bath Ankylosing Spondylitis Functional Index (BASFI); Health Assessment Questionnaire for the spondyloarthropathies (HAQ-s); Psoriatic arthritis quality of Life scale (PsAQoL); Short Form 36 (SF-36); Hospital Anxiety Depression Scale (HADS); Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); and Fibromyalgia Rapid Screening Tool (FiRST) scores. 31773391 2020
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease GWASCAT Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis. 30552173 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 Biomarker disease BEFREE Birth Outcomes and Disease Activity during Pregnancy in a Prospective Cohort of Women with Psoriatic Arthritis and Ankylosing Spondylitis. 31074583 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 Biomarker disease BEFREE Impact of Comorbidity on Physical Function in Patients with Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics. Results from the CARdiovascular in rheuMAtology (CARMA) study. 31033231 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 Biomarker disease BEFREE Secukinumab Immunogenicity over 52 Weeks in Patients with Psoriatic Arthritis and Ankylosing Spondylitis. 31203228 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE The effectiveness of TNFi in AS and PsA was 55% to 59% at 4 months and 75% to 96% at 3 years, as measured by a 50% decrease in the Bath Ankylosing Spondylitis Disease Activity Index from baseline. 29517554 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE In PSUMMIT 1 and 2, patients with PsA were randomized to placebo or ustekinumab 45 mg or 90 mg. Enthesitis was assessed at weeks 0 and 24 (Maastricht Ankylosing Spondylitis Enthesitis Score). 30936281 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 Biomarker disease BEFREE Genetic Polymorphisms of <i>Toll-like receptors 2</i> and <i>9</i> as Susceptibility Factors for the Development of Ankylosing Spondylitis and Psoriatic Arthritis. 31781672 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE A variety of clinical indices exist to assess enthesitis in PsA; however, the Leeds Enthesitis Index and Maastricht Ankylosing Spondylitis Enthesitis Score index have been the most frequently used indices in recent clinical trials. 29429762 2018
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE PROMs measuring COS domains with at least fair quality evidence for good validity and reliability (and no evidence for poor properties) included the Stockerau Activity Score for PsA (German), Psoriasis Symptom Inventory, visual analogue scale for Patient Global, 36 Item Short Form Health Survey Physical Function subscale, Health Assessment Questionnaire Disability Index, Bath Ankylosing Spondylitis Functional Index, PsA Impact of Disease questionnaire, PsA Quality of Life questionnaire, VITACORA-19, Functional Assessment of Chronic Illness Therapy Fatigue scale and Social Role Participation Questionnaire. 29037523 2018
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 Biomarker disease BEFREE HLA-B*27 is associated with more severe sonographic enthesitis in PsA, particularly in patients with longer disease duration. 29361203 2018
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE After controlling for the age of psoriasis onset no association of PsA to HLA-C*06:02 (p=0.07) was observed; instead, the most significant association was to amino acid at position 97 of HLA-B (p=1.54×10<sup>-9</sup>) where the presence of asparagine or serine residue increased PsA risk. 28821532 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE Obesity is linked with late-onset psoriasis and PsA, while normal weight is associated with the presence of the HLA-B*27 allele and an earlier onset of the disease. 28202737 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 Biomarker disease BEFREE Regression analysis demonstrated a significant association of SI with peripheral joint erosions (p=0.043), PASI maximum (p=0.041), younger age of PsA onset (p=<0.001), presence of HLA-B*0801 (p=0.002) and only marginal significance with HLA-B*2705 (p=0.059). 27974100 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 AlteredExpression disease BEFREE The relationship between disease activity or clinical response during the first 12 weeks of treatment and achievement of week-48 targets (for axial SpA: inactive disease based on Ankylosing Spondylitis Disease Activity Score [ASDAS] using the C-reactive protein [CRP] level, or Bath Ankylosing Spondylitis Disease Activity Index <2 with normal CRP level; and for PsA: minimal disease activity) was assessed post hoc using RAPID-axSpA and RAPID-PsA trial data. 27696727 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE Flare was defined as change in 28 Joint Disease Activity Score (∆DAS28) ≥1.2 (RA/PsA) or Ankylosing Spondylitis Disease Activity Score (∆ASDAS) ≥1.3 (AxSpA). 28473425 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE To explore the potential genotypic effects of pairwise combinations of different HLA-B and C alleles/haplotypes, we created a series of allele/haplotype risk scores combining single alleles/haplotypes separately associated with being in the highest PsA severity propensity tertile based on the features studied by univariate analysis. 25261574 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 Biomarker disease BEFREE Clearly, PsV and PsA are highly variable in terms of their clinical manifestations, and this heterogeneity can partially be explained by differences in HLA-associations (HLA-Cw*0602 versus HLA-B*27, for example). 26780035 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE Moreover, the genotype of patients in the PsA cohort was shown to be heterogeneous with significant elevations in the frequency of haplotypes containing HLA-B*08, HLA-C*06:02, HLA-B*27, HLA-B*38 and HLA-B*39. 25948071 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease GWASCAT Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. 26626624 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE The human leukocyte antigen-C0602 allele confers the highest risk for psoriasis whereas several human leukocyte antigen-B alleles were identified as 'PsA-specific' genes. 25415529 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE This large case-control and family based association study shows that HLA-C*12/B*38, HLA-B*27 and HLA-C*06/B*57 are haplotypes (alleles) robustly associated with PsA. 23916976 2013
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 Biomarker disease BEFREE The MICA-129 methionine (Met) allele, particularly Met/Met homozygosity, was strongly associated with both cutaneous psoriasis (PsC) and psoriatic arthritis (PsA) independently of HLA-B and HLA-C in Toronto patients, and was also associated with PsA in St. John's patients, but with no additional effect of Met/Met homozygosity. 23611695 2013
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE Certain HLA-B and HLA-C alleles confer susceptibility to PsA among patients with psoriasis and may be used to identify patients with PsC who may develop PsA. 21900282 2012
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.200 GeneticVariation disease BEFREE The following HLA alleles were over-transmitted to PsA compared with psoriasis: HLA-C*12 (p=0.005), HLA-B*38 (p=0.04), HLA-B*39 (p=0.03), HLA-B*27 (p=0.002). 22586163 2012