|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the distribution of DRB1, DQA1, DQB1, and DPB1 allelic variants in 48 rheumatoid arthritis (RA) patients, compared with 109 Italian random controls, using PCR amplification and hybridization with specific oligonucleotides.
|
1429034 |
1992 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the DPB1 0401 homozygous frequency was increased in DR4-negative RA patients.
|
1542871 |
1992 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
With our previous finding that DPB1*0301 is increased in seronegative children with polyarticular-onset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.
|
1930320 |
1991 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No contribution of any DQA1, DQB1, DPA1 or DPB1 alleles to RA susceptibility could be detected.
|
2095004 |
1990 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Southern blot analysis of HLA-DP gene polymorphisms in Caucasoid rheumatoid arthritis (RA) patients and controls.
|
2476386 |
1989 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis.
|
2512583 |
1989 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DP in rheumatoid arthritis.
|
3259737 |
1988 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The prevalence of the DPB1*0402 allele was higher in seropositive RA patients and DPB1*0201 was higher in seronegative RA patients.
|
8039286 |
1994 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
DNA-based HLA typing for DRB1, DQB1, and DPB1 was performed on 16 consistently RF--patients with erosive RA.
|
8182623 |
1994 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DPA1 and HLA-DPB1 in rheumatoid arthritis and its subsets.
|
8358964 |
1993 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DPB1 alleles were not related to the clinical manifestations of patients with RA in Taiwan.
|
8596140 |
1995 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
No association was seen between RA and HLA-DPB1 type.
|
9098407 |
1993 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
When HLA-DPB1 allelic frequencies were compared between seropositive RA patients and controls, a negative association for DPB1*0301 and DPB1*0401 was found in RA patients, although it failed to reach statistical significance after correction for the number of comparisons made.
|
9098423 |
1994 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
On another hand, the analysis of the HLA-DPB1 locus showed that the DPB1 *0401 allele frequency was significantly increased in the RA patient group (n = 47) who expressed only arginine at the position 71 of the beta 1 chain (82% vs 56% in controls, p < 0.008), with role of HLA-DR--DR and -DR-DP interactions in the genetic susceptibility to RA.
|
9157088 |
1996 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DPB1*0401 may function in addition to HLA-DRB1*04, whereas HLA-DPB1*0201 and -DPB1*0601 may represent additional risk factors among (Q)R/KRAA-negative RA patients.
|
9442804 |
1997 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The role of DPB1 remains hypothetical but may involve an influence of some alleles in relatively mild forms of RA.
|
11235775 |
2001 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
DPB1*0601 is reported to be a risk factor among RA patients, and glutamate at position 69 of the DPB1 molecule may be involved.
|
15703453 |
2005 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
CTD_human |
Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease.
|
17956852 |
2008 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DPB1 is an independent risk locus for ACPA-positive RA.
|
19116921 |
2009 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
HLA-DPB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of these, four loci showed the strongest associations with RA (P<0.005): ZNF391, the olfactory receptor (OR) gene cluster, C6orf26-RDBP and HLA-DPB1-COL11A2.
|
21293383 |
2011 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
CTD_human |
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.
|
22286218 |
2012 |
|
HLA-DPB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, DPB1*02:01, DPB1*04:01 and DPB1*09:01 conferred RA risk/protection independently from DRB1.
|
22471586 |
2012 |