Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE Our data also suggest a possible mechanism contributing to rheumatoid arthritis pathogenesis, whereby miR-146a expression is increased but unable to properly function, leading to prolonged tumor necrosis factor-alpha production in patients with rheumatoid arthritis. 18759964 2009
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE To investigate genotype-phenotype correlation and gene-environment interaction between PTPN22 R620W environmental factors such as tobacco/hormonal treatments in an inception cohort of RA patients. 21752868 2011
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE Similarly, the presence or absence of the HLA-DRB1 shared epitope or the RA-associated PTPN22 allele had no influence on this association. 18812394 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE This and other modulators of TNF receptor or the Fas apoptosis pathway may be therapeutically beneficial in facilitating apoptosis of synovial tissue in patients with RA. 10817564 2000
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts. 23335080 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE Tumor necrosis factor locus polymorphisms in rheumatoid arthritis. 9331953 1998
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 Biomarker disease BEFREE The application of ICSNPathway analysis to the meta-analysis results of RA GWAS datasets indicated candidate SNPs and pathways involving HLA-DMA, PTPN22, and TNAIP3 associated with RA susceptibility. 23582631 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE In vitro, the intracellular expression of galectin 3 in RA and OA synovial fibroblasts after modulation with tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and anti-CD40 monoclonal antibodies was measured by flow cytometry. 14558084 2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE To investigate both the involvement of chemokines in general and the relative importance of specific chemokines in rheumatoid arthritis (RA), we characterized the effect of the monokines tumor necrosis factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the synthesis of neutrophil-activating factors by synovial fibroblasts isolated from the joints of patients with RA. 8216423 1993
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE We have investigated the potent influence of some cytokines, tumour necrosis factor-alpha (TNF-alpha), platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and interferon-gamma (IFN-gamma), on the secretion of cysteine proteinases (cathepsins B and L) by cultured synovial fibroblast-like cells from patients with rheumatoid arthritis (RA). 9255106 1997
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population. 28500376 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE AdSPRY2 treatment suppressed the production of proinflammatory cytokines and matrix metalloproteinases (MMPs), and the cell proliferation, induced by TNFα in RA FLS. 26265114 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease LHGDN Association of a missense single nucleotide polymorphism in codon 620 of the PTPN22 with rheumatoid arthritis from a UK caucasian population. 15641088 2005
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE PTPN22 -1123G>C polymorphism and anti-cyclic citrullinated protein antibodies in rheumatoid arthritis. 28291534 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE Understanding the posttranscriptional regulation of TNFalpha biosynthesis is important for the development of novel treatment strategies in rheumatoid arthritis. 12115244 2002
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status. 15674368 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE VEGF secreted by RA synovial fibroblasts cultured in the presence of IL-6, IL-1beta, and/or tumor necrosis factor alpha (TNFalpha) was measured. 12794819 2003
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease LHGDN Strength of association between rheumatoid arthritis and the PTPN22 promoter polymorphism, -1123G > C, is analogous to that observed for 1858C > T. 17661906 2007
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 Biomarker disease LHGDN Both the FCRL3 and PTPN22 genes play roles in rheumatoid arthritis susceptibility, but in different individuals. 17133579 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE The interaction between CXCL10 and tumor necrosis factor-α (TNF-α) can also contribute to sustained inflammation in RA. 23092582 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Paired synovial biopsy samples were obtained from the affected knee of anti-TNF-resistant RA patients before (time 0) and 12 weeks after (time 12) initiation of rituximab therapy. 21337318 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE To determine whether the tumor necrosis factor (TNF)-receptor associated factor 1/complement component 5 (TRAF1/C5) polymorphism (rs10818488) confers susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematous (SLE), a meta-analysis was performed. 23321589 2013
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 Biomarker disease LHGDN The association of PTPN22 1858C > T poymorphism in Dutch cohort of juvenile type 1 diabetes and rheumatoid arthritis cohort was confirmed. 15875058 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE In particular, the relative copy number of TNF-alpha mRNA increased dramatically from 15 to 3554 in synovial cells from RA patients. 11174466 2001
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE Mortality studies were performed in the NOAR cohort (2432 patients; recruitment: 1990-2007; 2011 as final follow-up) and studies of treatment response in the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort (1846 patients enrolled at initiation of TNF inhibitor; recruitment: 2006-2010; 2011 as final follow-up). 25919528 2015