Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE In conclusion, we found an association between PTPN22 rs2476601 and EGFR rs17337023 polymorphisms and the risk of RA in a sample of Iranian population. 23350658 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE To investigate both the involvement of chemokines in general and the relative importance of specific chemokines in rheumatoid arthritis (RA), we characterized the effect of the monokines tumor necrosis factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the synthesis of neutrophil-activating factors by synovial fibroblasts isolated from the joints of patients with RA. 8216423 1993
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Pairwise-tagging single nucleotide polymorphisms (SNPs) spanning 24 candidate genes were selected and genotyped in a large UK cohort of patients receiving anti-TNF therapy for RA. 20448286 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Presence of anti-cyclic citrullinated peptide antibodies is associated with better treatment response to abatacept but not to TNF inhibitors in patients with rheumatoid arthritis: a meta-analysis. 31770089 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE This study identifies a potentially important role for TNF-α rs1800629 polymorphisms in the susceptibility to RA.However, further studies in larger cohorts are required. 25263964 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE Variations in two genes of the tumour necrosis factor (TNF) alpha pathway have been implicated in the pathogenesis of autoimmune diseases: polymorphisms in the TNFRSF1A gene, encoding TNF receptor 1, showed significant association with MS in genomewide association scans, and variation in or near the TNFAIP3 gene, coding for a negative regulator of NFkB, was associated with MS, systemic lupus erythematosus, diabetes and rheumatoid arthritis. 25684197 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis. 25896534 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE TCZ-SC, alone or with a csDMARD, yielded rapid and sustained efficacy in DMARD/anti-TNFα-IR RA patients, with acceptable toxicity.Home administration seems feasible. 30421069 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE At baseline, TTP and HuR gene expression levels, as well as the TTP:TNFalpha, TTP:HuR, and TIA-1:TNFalpha gene expression ratios were lower in patients with RA than in control subjects, while expression of TNFalpha, TIA-1, and TIA-1:HuR was higher in patients with RA. 17599736 2007
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE Gene-environment associations are important in rheumatoid arthritis (RA) susceptibility, with an association existing between smoking, HLA- DRB1 'shared epitope' alleles, PTPN22 and antibodies to cyclic citrullinated peptides (CCP). 19898480 2009
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE In contrast with a study of American patients with RA no evidence of association with PTPN22 independent of the well-characterised R620W variant was found, suggesting that in these patients this variant alone explains the association with the PTPN22 gene. 17170052 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Strategies based on TDM of TNF inhibitors seem promising for RA, but randomized controlled trials are required to support this. 28700520 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE PreproET mRNA expression increased in PBMCs from rheumatoid arthritis (RA) patients but returned to basal level in PBMCs from patients under anti-TNF therapy. 22249931 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. 24523570 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Conversely, Th17 cells and their effector molecules interleukin 17A (IL-17A), IL-17F, interferon (IFN)γ, tumor necrosis factor (TNF)α, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are implicated in the pathology of rheumatoid arthritis (RA). 29254845 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals. 24665115 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE This study investigated the added value of US to clinical variables in predicting flare in RA patients with longstanding low disease activity when stopping TNF inhibitors (TNFi). 28595367 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE These results exclude the possibility of involvement of the TNFA genes (TNF-alpha) in the development of RA, which was suggested previously to be a strong candidate for RA in the class III region. 11170743 2001
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE Eighty-one patients with active RA were genotyped for the -308 TNFalpha polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and subdivided into two groups for each polymorphism (G/A and G/G genotype). 17343250 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE To evaluate the efficacy and safety of interleukin 17 (IL-17) inhibitors in two rheumatoid arthritis (RA) populations: biologic-naïve or tumor necrosis factor inhibitor inadequate responders (TNF-IR). 31165341 2019
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. 18075792 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Tumor necrosis factor-α (TNF-α) inhibitors are increasingly being used as treatment for rheumatoid arthritis (RA). 28260984 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE Mycobacterial diseases are prevalent in cancer and rheumatoid arthritis (RA) patients, especially those receiving tumor necrosis factor-α inhibitor (TNFi). 28737121 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE Accumulating evidences suggested that tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs10499194, rs13207033 polymorphisms may be associated with the risk of rheumatoid arthritis (RA). 27779104 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE We evaluated healthcare utilization before and after initiation of the tumor necrosis factor inhibitor etanercept in patients with moderate to severe RA. 28770517 2017