Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Increased risk of RA was associated with having any child compatible at HLA-B (OR 1.9; 1.2-3.1), DPB1 (OR 1.8; 1.2-2.6) or DQB1 (OR 1.8; 1.2-2.7). 30635658 2020
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Strong association was observed between SNP rs9277535 in HLA-DP and RA susceptibility (allele frequency distribution: OR = 1.409, 95%CI = 1.121-1.773, P = 0.004). 29476350 2018
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65-0.94). 30235330 2018
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 AlteredExpression disease BEFREE This meta-analysis demonstrates that high frequency expression of DPB1*0401 and *0601 are significantly associated with susceptibility to RA, it may be a risk factor for occurrence of RA. 29425827 2018
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE We tested the association between having any child with alleles encoding amino acids (AAs) associated with RA including the 'shared epitope' (SE) and DERAA AA sequences at positions 70-74; AA valine, lysine and alanine at positions 11, 71 and 74 of HLA-DRB1; aspartic acid at position 9 of HLA-B and phenylalanine at position 9 of DPB1. 28391248 2017
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE A weighted genetic risk score (wGRS) was created using 45 RA non-human leucocyte antigen (HLA) susceptibility loci, imputed amino acids at HLA-DRB1 (11, 71 and 74), HLA-DPB1 (position 9) HLA-B (position 9) and gender. 24092415 2015
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE HLA-DPB1*05:01 was the only allele associated with the presence of both anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese RA and SLE patients. 23320107 2013
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease CTD_human Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. 22286218 2012
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE However, DPB1*02:01, DPB1*04:01 and DPB1*09:01 conferred RA risk/protection independently from DRB1. 22471586 2012
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease GWASDB A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. 21156761 2011
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Of these, four loci showed the strongest associations with RA (P<0.005): ZNF391, the olfactory receptor (OR) gene cluster, C6orf26-RDBP and HLA-DPB1-COL11A2. 21293383 2011
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE HLA-DPB1 is an independent risk locus for ACPA-positive RA. 19116921 2009
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease GWASDB REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. 19503088 2009
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease CTD_human Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease. 17956852 2008
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease GWASDB TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. 17804836 2007
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE DPB1*0601 is reported to be a risk factor among RA patients, and glutamate at position 69 of the DPB1 molecule may be involved. 15703453 2005
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE The role of DPB1 remains hypothetical but may involve an influence of some alleles in relatively mild forms of RA. 11235775 2001
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE HLA-DPB1*0401 may function in addition to HLA-DRB1*04, whereas HLA-DPB1*0201 and -DPB1*0601 may represent additional risk factors among (Q)R/KRAA-negative RA patients. 9442804 1997
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE On another hand, the analysis of the HLA-DPB1 locus showed that the DPB1 *0401 allele frequency was significantly increased in the RA patient group (n = 47) who expressed only arginine at the position 71 of the beta 1 chain (82% vs 56% in controls, p < 0.008), with role of HLA-DR--DR and -DR-DP interactions in the genetic susceptibility to RA. 9157088 1996
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE HLA-DPB1 alleles were not related to the clinical manifestations of patients with RA in Taiwan. 8596140 1995
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE The prevalence of the DPB1*0402 allele was higher in seropositive RA patients and DPB1*0201 was higher in seronegative RA patients. 8039286 1994
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE When HLA-DPB1 allelic frequencies were compared between seropositive RA patients and controls, a negative association for DPB1*0301 and DPB1*0401 was found in RA patients, although it failed to reach statistical significance after correction for the number of comparisons made. 9098423 1994
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE DNA-based HLA typing for DRB1, DQB1, and DPB1 was performed on 16 consistently RF--patients with erosive RA. 8182623 1994
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE HLA-DPA1 and HLA-DPB1 in rheumatoid arthritis and its subsets. 8358964 1993
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease BEFREE No association was seen between RA and HLA-DPB1 type. 9098407 1993