|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*03 may be implicated in the susceptibility to asthma in the pediatric population.
|
24962747 |
2014 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the role of the HLA DRB1*03 in asthma susceptibility is independent of ancestral-haplotype-mediated linkage disequilibrium.
|
20735759 |
2010 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*03 tended to be increased in mold-sensitive moderate-severe asthmatics.
|
20486920 |
2010 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype may be a genetic marker for the development of TDI-induced asthma in Koreans.
|
19439981 |
2009 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data suggests that HLA-DRB1, DQA1 & DQB1 alleles and haplotypes might be implicated in susceptibility to allergy and asthma and serum IgE production.
|
19052351 |
2008 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The HLA-A*24, HLA-Cw*12, and HLA-DRB1*04 alleles were determined to be significantly higher in the NP patients with asthma and ASA triad (P < 0.05).
|
18922348 |
2008 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We concluded that the HLA DRB1*03 allele is associated with asthma.
|
17212706 |
2007 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data suggests that asthma is not associated with DRB1 or DQB1 but rather TNFA or a gene(s) in linkage disequilibrium, while sensitization to specific allergens is associated with particular alleles at the DQ and/or DR loci.
|
17686102 |
2007 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
CTD_human |
The HLA haplotype DRB1*15-DPB1*05 can be a susceptibility gene marker for the development of TDI-induced asthma among the exposed workers in the Korean population.
|
16792590 |
2006 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The HLA haplotype DRB1*15-DPB1*05 can be a susceptibility gene marker for the development of TDI-induced asthma among the exposed workers in the Korean population.
|
16792590 |
2006 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
In haplotype analysis, the HLA-DRB1(*)1302-DQB1(*)0609-DPB1(*)0201 was significantly higher in the aspirin-induced urticaria (8.0%) than in the aspirin-intolerant asthma (0.7%, P=0.0014) and normal controls (2.0%, P=0.0006).
|
15784113 |
2005 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
The transmission disequilibrium test detected excess transmission of HLA-DRB1*03 and of the haplotype TNF2/DRB1*03 (p = 0.03 and 0.04, respectively) to siblings with asthma and ST positivity to Lolium and of HLA-DRB1*1104 and of the haplotype TNF2/DRB1*1104 (p = 0.04 and 0.015, respectively) to siblings with asthma and ST positivity to Parietaria.
|
12590981 |
2003 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 alleles did not predict the presence of asthma, but multi-allelic tests of association showed the locus accounted for approximately 33% of the variance of the total serum IgE concentration and 17% of the variance of the specific IgE titres to HDM.
|
12620968 |
2003 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
HLA-DRB1 alleles did not predict the presence of asthma, but multi-allelic tests of association showed the locus accounted for approximately 33% of the variance of the total serum IgE concentration and 17% of the variance of the specific IgE titres to HDM.
|
12620968 |
2003 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found between HLA-DRB1*02, B5* haplotype and asthma phenotype in patients with grass-pollen allergy when compared to patients with rhinitis only.
|
12166586 |
2002 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that HLA-DRB1 alleles modulate the total serum IgE concentration and IgE responses to allergens, but do not account for the previous observations of linkage of asthma to the MHC.
|
11378822 |
2001 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1* and DQB1* HLA class II, TCR-Valpha8.1, FcepsilonRI-beta Rsa I exon 7 and intron 2, TNF-beta (LTalpha-Nco I) and CD14, were tested for association with asthma and atopy by multiple regression analysis, in 5 families comprising 87 individuals.
|
11574751 |
2001 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No significant difference was found in the distribution of DRB1 alleles between asthmatics and controls.
|
10792356 |
2000 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 genes may be involved in the development of CRM-induced asthma.
|
11069565 |
2000 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There were no significant differences among asthmatic and atopic controls in the frequency of HLA-DRB1*11 (25.6 vs 17.4%).
|
10051703 |
1999 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Results showed that HLA-DRB1*08 was negatively associated with asthma (2% vs 17%; Pc = 0.02; OR = 0.08) and atopy (0% vs 16%; Pc = 0.04; OR = 0.1), while DRB1*15 was positively associated with asthma (36% vs 13%; Pc = 0.02; OR = 3.6).
|
10641564 |
1999 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The rarer LTalpha NcoI*1/TNF-308*2/HLA-DRB1*02 haplotype, which was found in 0.6% of unrelated subjects, was more strongly associated with asthma (OR = 6.68, p = 0.002).
|
10456966 |
1999 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated the human leukocyte antigen (HLA) genes DRB1,3,4,5, DQB1, and DQA1 in 55 isocyanate-exposed patients with workplace-related dyspnea (32 asthmatics, 23 nonasthmatics) and 90 nonexposed controls.
|
9327077 |
1997 |