Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE In summary, our experiments elucidated that the HIF‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced autophagy in glioblastoma and astrocytoma. 30569180 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease BEFREE The values of ADC, RSIGd, EP, EI, cellular density and the expression of HIF-1α were changed with the malignant degree of astrocytoma to some extent, but not every quantitative parameter was related to the expression of HIF-1α. 28006727 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease BEFREE The results demonstrate that increased expression and activity of LOX, BMP1 and HIF1A were positively correlated with the malignant grade of astrocytomas. 25790191 2015
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease BEFREE CXCR7, CXCR4 and HIF1α mRNA expression were evaluated in 129 frozen samples of astrocytomas. 24970694 2015
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 GeneticVariation disease BEFREE To study the putative expression patterns and clinical significance of Hsp27, we assessed the associations between Hsp27, R132H mutation of Isocitrate dehydrogenase1 (IDH1-R132H), Hypoxia-inducible factor subunit alpha (HIF-1 alpha), Carbonic anhydrase IX (CA IX), and patient prognosis in astrocytic gliomas. 24599602 2014
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease BEFREE Since glioblastoma multiforme is the epitome of a highly aggressive tumor entity, while lower-grade astrocytomas often show a prolonged clinical course, a profound difference in the extent of hypoxic tissue areas and corresponding magnitude of HIF-1 activity may exist between these entities. 22825389 2012
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE We believe that HIF-1alpha and iNOS expressions merit further investigations in order to understand the biology of astrocytic gliomas. 16724682 2006
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE Similarly, RGS-5 is overexpressed in highly angiogenic astrocytomas but not in hypoxia-inducible factor-1alpha (HIF-1alpha)-deficient tumors, which grow along preexisting brain capillaries without inducing neovessels. 15459006 2005
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease CTD_human Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. 15341671 2004
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease BEFREE Expression of HIF-1alpha, VEGF, Ki-67 (a proliferation-associated marker) and p53 was determined immunohistochemically in 83 adult patients with supratentorial diffuse astrocytomas. 15175080 2004
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease LHGDN Expression of HIF-1alpha, VEGF, Ki-67 (a proliferation-associated marker) and p53 was determined immunohistochemically in 83 adult patients with supratentorial diffuse astrocytomas. 15175080 2004
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease BEFREE HIF-1 mediated gene expression may be directly or indirectly modulated by alterations in oncogenes/tumor suppressor genes that occur during astrocytoma development, including PTEN, TP53, p16(CDKN2A), p14ARF, EGFR, and PDGFR. 12456339 2003