Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 Biomarker disease BEFREE The algorithm measured significant increase in F-actin at cell edges with concomitant decrease in internal punctate actin in astrocytoma cells lacking functional neurofibromin and p53 when treated with three structurally-distinct anticancer small molecules: OSW1, Schweinfurthin A (SA) and a synthetic marine compound 23'-dehydroxycephalostatin 1. 24515854 2014
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 Biomarker disease CTD_human Bioluminescent approaches for measuring tumor growth in a mouse model of neurofibromatosis. 20176786 2010
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 GeneticVariation disease BEFREE Analyzed astrocytomas without mutations in Ras or neurofibromin may harbor mutations in other proteins of this pathway leading to hyperactive Ras signaling. 17712732 2007
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 PosttranslationalModification disease BEFREE However, no methylation was found at the NF1 promoter region in PA. To rule out that silencing of NF1 by promoter methylation is restricted to higher-grade astrocytomas, 15 pediatric WHO II degree and IV degree astrocytomas were analyzed: 12 astrocytomas II and 3 glioblastomas displayed no NF1 promoter methylation. 15770836 2005
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 Biomarker disease BEFREE Collectively, our results suggest that loss of neurofibromin is not sufficient for astrocytoma formation in mice and that other genetic or environmental factors might influence NF1-associated glioma tumorigenesis. 12077339 2002
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 Biomarker disease LHGDN Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas. 12387455 2002
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 Biomarker disease BEFREE Impaired neurofibromin function in these nervous system cells contributes to the development of astrocytomas, learning disabilities, and radiographic abnormalities of the brain. 12403558 2002
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 Biomarker disease BEFREE These results support a role for neurofibromin as the critical GAP in the molecular pathogenesis of NF1 astrocytomas. 11005256 2000
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 AlteredExpression disease BEFREE Furthermore, when levels of activated p21 ras were decreased in astrocytoma cells expressing the ras inhibitory Asn-17 dominant-negative mutant, levels of neurofibromin expression decreased. 8668337 1996
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 Biomarker disease HPO
Entrez Id: 4763
Gene Symbol: NF1
NF1
0.480 CausalMutation disease CLINVAR
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.450 AlteredExpression disease BEFREE High FGFR1 expression was associated with age, malignancy, tumor location and tumor grade among astrocytomas. 30931252 2019
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.450 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.450 GeneticVariation disease BEFREE Pediatric LGG show alterations in FGFR1 and BRAF in pilocytic astrocytomas and FGFR1 alterations in diffuse astrocytomas, each converging on the mitogen-activated protein kinase signaling pathway. 25664944 2015
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.450 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.450 AlteredExpression disease BEFREE Transplantation of Trp53-null neonatal astrocytes expressing FGFR1 with the duplication involving the TKD into the brains of nude mice generated high-grade astrocytomas with short latency and 100% penetrance. 23583981 2013
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.450 AlteredExpression disease BEFREE Glioblastoma (the most malignant form of astrocytoma) cell lines, which exhibit the same pattern of FGFR gene expression as glioblastoma biopsies, were used to evaluate the contribution of FGFR1 expression to glioblastoma cell growth. 10498824 1999
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.450 Biomarker disease BEFREE Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas. 7964981 1994
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.430 Biomarker disease BEFREE The cellular response to the recombinant NS1 protein of West Nile virus (NS1<sup>WNV</sup>) was studied using three different cell types: Vero E6 simian epithelial cells, SH-SY5Y human neuroblastoma cells, and U-87MG human astrocytoma cells. 31569658 2019
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.430 Biomarker disease BEFREE The above results revealed that although the expression levels of SOCS1, SOCS3 and, in particular, p‑SHP2, tend to decrease in the four types of astrocytomas, PIAS3 downregulation is more negatively correlated with STAT3 activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome. 28035384 2017
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.430 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.430 Biomarker disease CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572 2013
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
0.430 AlteredExpression disease BEFREE Although SHP-1 is uniquely expressed on hematopoietic cells, SHP-2 is ubiquitously expressed, so that SIRPalpha1 has the potential to function in many cell types, including astrocytomas. 14729615 2004
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE In summary, our experiments elucidated that the HIF‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced autophagy in glioblastoma and astrocytoma. 30569180 2019