Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 GeneticVariation disease BEFREE To conclude, IL-18 promoter -137G/C polymorphism influences IL-18 levels and the occurrence of coronary artery disease, suggesting that IL-18 is causally involved in the development of atherosclerosis. 18599493 2009
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 GeneticVariation disease BEFREE We report that common variation in the interleukin 18 gene is related to acute myocardial infarction, a frequent clinical manifestation of atherosclerosis and thrombosis in coronary arteries. 22015107 2011
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 GeneticVariation disease BEFREE Among all study subjects, the polymorphism of the IL-18 gene is not associated with subclinical markers of atherosclerosis. 20350254 2010
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Therefore, in order to investigate IL-18 contribution to the immuno-inflammatory processes underlying atherosclerosis, a systems approach has been used in our studies. 30400655 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Furthermore, we demonstrated the expression of IL-18BP in atherosclerotic lesions in a rhesus model of atherosclerosis, underscoring the need to fully understand the role of this protein as a primary negative regulator of IL-18 in multiple disease processes. 20663688 2010
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Atorvastatin inhibits IL-18-mediated aortic SMC migration and has therapeutic potential for attenuating the progression of atherosclerosis and restenosis. 16554298 2006
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Interleukin-18 is a pro-inflammatory cytokine suspected to be associated with atherosclerosis and its complications. 19473509 2009
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Indeed, IL-18 is involved in inflammatory tissue injuries, such as Crohn's disease and atherosclerosis, and also in hyper IgE and atopic dermatitis. 14527086 2003
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE It is now also known that cholesterol crystals are present through all stages of atherosclerosis and can activate the NLRP3 inflammasome within these inflammatory cells to produce interleukin 1β and interleukin 18 - key mediators in the inflammatory cascade that drive plaque progression and instability. 29352570 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Several studies have indicated a decisive and important role of NLRP3 inflammasome, IL-1β, IL-18, and pyroptosis in atherosclerosis. 28345767 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Variations of the IL18 gene consistently influence circulating levels of IL-18 and clinical outcome in patients with coronary artery disease, which supports the hypothesis of a causal role of IL-18 in atherosclerosis and its complications. 16043644 2005
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Activation of macrophage inflammasomes leads to interleukin (IL)-1β and IL-18 secretion and promotes atherosclerosis and its complications in mice and humans. 30782961 2019
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE In this article, we aimed to present an updated review on these aspects regarding the contribution of IL-18 to important diseases such as cancer, autoimmunity, and inflammatory-mediated conditions including allergic diseases, metabolic syndrome, and atherosclerosis. 29478963 2017
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Because both IL-18 and Angiotensin II (Ang II) are implicated in atherosclerosis, our objective was to analyze the role of IL-18 signaling and potential cross-talk with Ang II in VSMC. 15860756 2005
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE To examine the role of IL-18 in atherosclerosis, we determined the relation between IL-18 mRNA expression and signs of plaque instability using real-time quantitative PCR. 11581135 2001
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Interleukin 18 (IL-18) is suspected to play an important role in atherosclerosis and plaque vulnerability. 17487222 2007
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Together with recent reports, showing IL-18 to be predictive for cardiovascular events, our findings could provide the basis for further research of the role of IL-18 as a link and possible target in the association between MetS and atherosclerosis. 21842238 2011
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Pyroptosis is characterized by rapid plasma membrane rupture, with the consequent release of intracellular contents and pro-inflammatory mediators, including interleukin (IL)-1β, IL-18, and the alarmin HMGB-1.Recent studies have shown that pyroptosis may be involved in atherosclerosis and play an important role in atherosclerotic lesion instability. 29129476 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Biomarker disease BEFREE Our data demonstrate that TAE protects against IL-18-induced atherosclerosis via NF-κB/PPAR-γ-mediated pathway. 28547701 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 Therapeutic disease RGD Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats. 23685195 2013
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 AlteredExpression disease BEFREE Per os administration of colchicine did not influence atherosclerosis progression in cholesterol-fed rabbits, levels of IL-18, insulin and leptin. 28950870 2017
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 AlteredExpression disease BEFREE In addition, the AS group displayed the highest protein levels of TXNIP, NLRP3, ASC, caspase-1, IL-1β, and IL-18, while the levels of these proteins in the AS + H <sub>2</sub> S group were higher than those in the sham group. 30246263 2019
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 AlteredExpression disease LHGDN The association between IL-18 and atherosclerosis diminished after accounting for traditional cardiovascular risk factors. 17626902 2007
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 AlteredExpression disease BEFREE Moreover, when mice deficient in low-density lipoprotein receptor (LDLR) were bone-marrow transplanted with NLRP3-deficient, ASC (also known as PYCARD)-deficient or IL-1alpha/beta-deficient bone marrow and fed on a high-cholesterol diet, they had markedly decreased early atherosclerosis and inflammasome-dependent IL-18 levels. 20428172 2010
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.300 AlteredExpression disease BEFREE Moreover, the use of loss- or gain-of-function genetically modified, atherosclerosis-prone mice has provided strong experimental evidence for a causal role of innate and adaptive immunity in atherosclerosis and has revealed the pathogenic activity of proinflammatory cytokines, including TNF (tumor necrosis factor)-α, IL (interleukin)-1β, IL-6, and IL-18, and the atheroprotective effect of anti-inflammatory cytokines, including IL-10 and TGF-β. 31294625 2019