Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE It is assumed that the excess supply of angiotensin II (due to the deletion polymorphism of the angiotensin-converting enzyme gene) contributes to endothelial dysfunction and in this way promotes the onset and progression of atherosclerosis. 12143941 2002
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE To elucidate the discrepancy between HGF and VEGF, we compared the effects of HGF and VEGF on endothelial progenitor cells under angiotensin II stimulation, which is a well-known risk factor for atherosclerosis. 19047582 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population. 23497386 2013
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE To investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensinogen M235T or angiotensin II receptor type 1 573C/T polymorphism modify the risk of atherosclerosis associated with beta-blocker or ACE-inhibitor therapy. 17298481 2007
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Two of the 9 SNPs, rs2106261 (16q22) and rs6666258 (1q21), revealed interaction relationships that neared statistical significance (with point estimates in the same direction for angiotensin-converting enzyme inhibitor only and angiotensin II receptor blocker only analyses), but neither association could be replicated among 8,604 participants in Atherosclerosis Risk in Communities. 27179719 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Angiotensinogen and angiotensin converting enzyme genotypes and carotid atherosclerosis: the atherosclerosis risk in communities and the NHLBI family heart studies. 9678776 1998
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). 24942509 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE To assess the association of the angiotensin II type 2 (AT2) receptor (-1332 G/A) gene polymorphism with premature coronary artery disease (CAD) and investigate for a further role in both myocardial infarction and predominantly stenotic atherosclerosis requiring revascularisation. 17336987 2007
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE A missense gene mutation with methione-to-threonine amino acid substitution at codon 235 (M235T) of angiotensinogen (AGT) has been associated with higher plasma AGT levels and may influence the pathogenesis of cardiac hypertrophy and atherosclerosis. 10342781 1999
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Additionally, lncRNAs have been associated with angiotensin II actions and with vascular diseases, including coronary heart disease and atherosclerosis. miRNAs, well studied in various vascular diseases, have also been recently shown to be differentially expressed in the biofluids of patients with vascular disease and mediate cell-cell communication. 24614861 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes. 20945963 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II type 1 receptor antagonists (AIIA) are beneficial for the prevention of atherosclerosis and diabetic nephropathy suggesting that angiotensin II (Ang II) promotes the development of these diseases. 17487826 2007
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE <b>Conclusion:</b> RDN promoted atherosclerosis in apolipoprotein E-deficient mice infused with angiotensin II associated with upregulation of MMP-2. 28450836 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang-II), a vascular stimulant associated with cardiovascular disease progression, has been demonstrated to be mainly involved in cardiovascular remodeling of atherosclerosis and cardiac hypertrophy. 29369845 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Its effects on ROS production, AP-1 activity, plasminogen activator inhibitor 1 (PAI-1) gene expression, and cellular proliferation and migration were measured in response to high glucose and angiotensin II (Ang II) concentrations, two major factors in the pathogenesis of atherosclerosis in patients with diabetes and hypertension. 15827742 2005
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE In conclusion, administration of rAngpt2 attenuated angiotensin II-induced aortic aneurysm and atherosclerosis in ApoE<sup>-/-</sup> mice associated with reduced aortic inflammation and angiogenesis. 27767064 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Mice deficient both in ApoE and in kinin B1 receptor (ApoE(-/-)-B(1)(-/-)) were generated and analyzed for their susceptibility to atherosclerosis and aneurysm development under cholesterol rich-diet (western diet) and angiotensin II infusion. 19618151 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (AngII) type 1 receptor (AT1R) blockers have been proved to reduce atherosclerosis. 26771341 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE As both a vasoconstrictor and a proinflammatory mediator, angiotensin II (Ang II) is considered a potential link between hypertension and atherosclerosis. 29130930 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Cilostazol Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysms but Not Atherosclerosis in Apolipoprotein E-Deficient Mice. 29437572 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis. 30905257 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE The effects of angiotensin II, which may be at least partially genetically mediated, have been implicated in epidemiologic and clinical studies as a risk factor for the development of atherosclerosis. 11177655 2001
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE While adoptive transfer of B cells in Apoe <sup>-/-</sup> /Baffr <sup>-/-</sup> mice reversed atheroprotection in the absence of AngII, infusion of AngII in B cell replenished Apoe <sup>-/-</sup> /Baffr <sup>-/-</sup> mice unexpectedly prevented the progression of atherosclerosis. 28646220 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) infusion promotes the development of aortic aneurysms and accelerates atherosclerosis in ApoE<sup>-/-</sup> mice. 30048944 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through the AT<sub>1</sub>R/ROS/p38 MAPK/ADAM17 pathway. 31390228 2019