Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression disease LHGDN Lipid transfer protein activities in subjects with impaired glucose tolerance. 17311515 2007
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE In the presence of CETP, AET positively influences gene expression in the arterial wall and macrophages of CETP-tg mice contributing to the RCT and prevention of atherosclerosis. 29867549 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE CETP is susceptible to play a proatherogenic role since it mediates a redistribution of plasma cholesterol from lipoproteins associated with a protection against atherosclerosis into the proatherogenic apo B-containing lipoproteins. 8964591 1996
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE Re-evaluation of cholesteryl ester transfer protein function in atherosclerosis based upon genetics and pharmacological manipulation. 27454452 2016
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis. 19131637 2009
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression disease BEFREE To assess effects on atherosclerosis, ITX5061 was given to atherogenic diet-fed Ldlr(+/-) mice with or without CETP expression for 18 weeks. 19815817 2009
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE Chronic OSM administration in APOE*3Leiden.CETP mice reduced atherosclerosis development. 31461490 2019
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 GeneticVariation disease BEFREE However, the effects of CETP itself and its interaction with HDL-C have not been investigated in hemodialysis patients, who are at high risk for atherosclerosis and generally considered to have decreased reverse cholesterol transport. 11431184 2001
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression disease BEFREE We conclude that CETP expression reduces atherosclerosis in LCAT-Tg mice by restoring the functional properties of LCAT-Tg mouse HDL and promoting the hepatic uptake of HDL-CE. 10601244 1999
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE The inhibition of CETP can lead to substantial elevations in HDL-C. Based on a number of considerations, including the complex relationship between loss of function mutations in CETP and risk for CAD and the clinical experience with torcetrapib, it is difficult to predict if CETP inhibition will be associated with reductions in rates of atherosclerosis disease progression and risk for cardiovascular events. 21909703 2011
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 GeneticVariation disease BEFREE Hence, CETP gene polymorphisms may alter susceptibility to atherosclerosis. 14998629 2004
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE Here, we review the complex relationship between CETP and atherosclerosis based upon the experimental, clinical, and epidemiological studies. 21488146 2011
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression disease BEFREE These results provide evidence that genetic ablation of CETP activity protects against cholesterol diet-induced atherosclerosis in rabbits. 28428219 2017
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE We previously reported that patients with cholesteryl ester transfer protein (CETP) deficiency (CETP-D) have a higher prevalence of atherosclerotic cardiovascular disease, in spite of increased HDL-C levels. 29304079 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression disease BEFREE CETP restores HDL-C levels in SR-BI(KO) mice, but it does not change the susceptibility to atherosclerosis and other typical characteristics that are associated with SR-BI disruption. 20431066 2010
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE In the current study, to elucidate the clinical significance of and atherogenicity in marked HALP, we determined the incidence of atherosclerotic cardiovascular disease (ACD) in patients with marked HALP and characterized the lipoprotein abnormalities in those who had ACD, focusing especially on CETP and HTGL. 7583564 1995
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE However, the pathophysiological significance of CETP in terms of atherosclerosis has been controversial. 15256762 2004
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE This review discusses the potential of CETP inhibitors to protect against atherosclerosis in the context of the current knowledge of CETP function in both rodents and humans. 15342674 2004
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein). 29674325 2018
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE In contrast, hyperalphalipoproteinemia as a result of loss of cholesteryl ester transfer protein function is associated with unaltered atherosclerosis progression compared with family controls. 15767853 2005
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE Soy protein containing isoflavones favorably influences macrophage lipoprotein metabolism but not the development of atherosclerosis in CETP transgenic mice. 17069349 2006
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE The possible glycosylation in the tree shrew CETP may be involved in the molecular mechanism of its insusceptibility to atherosclerosis. 12877809 2003
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 AlteredExpression disease BEFREE In addition to the apparent antiatherogenic phenotype of human genetic CETP deficiency, high level expression of CETP in transgenic mice leads to accelerated atherosclerosis, illustrating the pro-atherogenic potential of CETP expression. 7830031 1995
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 Biomarker disease BEFREE E3L.CETP mice were fed a high-cholesterol diet for 11 weeks to induce atherosclerosis, followed by a low-cholesterol diet for 4 weeks to obtain a lower plasma total cholesterol level of approximately 10 mmol.L(-1). 19220285 2009
Entrez Id: 1071
Gene Symbol: CETP
CETP
0.400 GeneticVariation disease BEFREE We genotyped the CETP R451Q, A373P, -629C/A, Taq1B, and -2505C/A polymorphisms in a cohort of Caucasian, Chinese, African-American, and Hispanic individuals within the Multi-Ethnic Study of Atherosclerosis. 18243217 2008