Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE In this study we explored the microRNAs responsible for the regulation of PAI-1 during LPS-stimulated inflammation in human aortic endothelial cells and subsequently studied the effect of a newly synthesized mitochondria-targeted esculetin (Mito-Esc) that was shown for its anti-atherosclerotic potential, in modulating PAI-1 levels and its targeted miRs during angiotensin-II-induced atherosclerosis in ApoE<sup>-/-</sup> mice. 28213977 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE This study was designed to investigate the effect of the angiotensin II receptor blocker olmesartan alone, or in combination with standard treatment with a statin, pravastatin, on atherosclerosis development in APOE*3Leiden transgenic mice. 17984667 2007
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE This spontaneous model recapitulates aspects of human atherosclerosis, and allows for the development of dissecting abdominal aortic aneurysms (AAAs) when combined with angiotensin II. 29166645 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (ANG II) type 1 (AT1)-receptor blockade reduces LDL-modification and atherosclerotic plaque formation in rodent and primate models of atherosclerosis. 17069818 2007
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II is well-recognised to be a key mediator in driving the pathological events of diabetes-associated atherosclerosis via signalling through its angiotensin II type 1 receptor (AT1R) subtype. 27168137 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) is a critical factor in inflammatory responses, which promotes the pathogenesis of atherosclerosis. 20500895 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE However, endothelial-specific Nox2 overexpression did not alter native or angiotensin II-driven atherosclerosis in either the aortic root or the descending aorta. 22287576 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Since a crosstalk between AGE and angiotensin II (Ang II) has been proposed in the pathogenesis of accelerated atherosclerosis in diabetes, we examined here whether and how telmisartan, a unique Ang II type 1 receptor blocker (ARB) with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity, could inhibit AGE-induced CRP expression in a human hepatoma cell line, Hep3B cells. 17004092 2006
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) is implicated in the development of cardiovascular disorders including hypertension and atherosclerosis. 29609002 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE To accelerate the development of atherosclerosis, apolipoprotein E knockout mice were infused with angiotensin II (0.72 mg·kg<sup>-1</sup>·d<sup>-1</sup> subcutaneous) for 28 days. 30586752 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE The oxidases are also upregulated in vascular disease and are involved in the development of atherosclerosis and a significant part of angiotensin II-induced hypertension, possibly via nox1 and nox4. 12855411 2003
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) and macrophage apoptosis are involved in the pathogenesis of atherosclerosis. 31155290 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (AngII) induces hypertension and pathophysiological vascular thickening and atherosclerosis. 31302653 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE Angiotensin II (Ang II) regulates the expression of some core clock genes; excess Ang II leads to atherosclerosis advancement. 29590657 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) is a bioactive peptide that is related to cardiovascular disease such as atherosclerosis, whereas angiotensin-(1-7) (Ang-(1-7)) is a counter-regulator of angiotensin II, which protects against cardiovascular disease. 28283184 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE In conclusion, MRKO reduces high cholesterol- or angiotensin II-induced atherosclerosis and favorably changes plaque composition, likely improving plaque stability. 27881672 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Angiotensinogen and angiotensin converting enzyme genotypes and carotid atherosclerosis: the atherosclerosis risk in communities and the NHLBI family heart studies. 9678776 1998
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). 24942509 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Agonistic autoantibodies against angiotensin II type 1 (AT1) receptor (AT1-AAs) have been demonstrated to be pro-inflammatory and contribute to the progression of atherosclerosis. 31595199 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone. 15123520 2004
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Moreover, CRISPR-Cas9-mediated deletion of candidate enhancers/SEs, targeting SEs with the bromodomain and extra-terminal domain inhibitor JQ1, or knockdown of overlapping long noncoding RNAs (lncRNAs) blocks AngII-induced genes associated with growth-factor signaling and atherosclerosis. 29133788 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE To assess the association of the angiotensin II type 2 (AT2) receptor (-1332 G/A) gene polymorphism with premature coronary artery disease (CAD) and investigate for a further role in both myocardial infarction and predominantly stenotic atherosclerosis requiring revascularisation. 17336987 2007
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE (2) In an accelerated atherosclerosis model, with angiotensin II-induced aortic lesions and aneurysms, A-002 (30 mg/kg twice a day) reduced aortic atherosclerosis by approximately 40% (P < 0.05) and attenuated aneurysm formation (P = 0.0096). 19129734 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE During active disease, patients with granulomatosis with polyangiitis (GPA; Wegener's granulomatosis) have accelerated atherosclerosis and ANGII inhibitors are recommended to these patients to reduce atherosclerosis. 21936613 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Parenteral administration of enoxaparin (FXa/IIa inhibitor) and fondaparinux (FXa inhibitor) over 14 days reduced to severity of aortic aneurysm and atherosclerosis in AngII-infused ApoE<sup>-/-</sup> mice. 28220880 2017