Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE To elucidate the discrepancy between HGF and VEGF, we compared the effects of HGF and VEGF on endothelial progenitor cells under angiotensin II stimulation, which is a well-known risk factor for atherosclerosis. 19047582 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE (2) In an accelerated atherosclerosis model, with angiotensin II-induced aortic lesions and aneurysms, A-002 (30 mg/kg twice a day) reduced aortic atherosclerosis by approximately 40% (P < 0.05) and attenuated aneurysm formation (P = 0.0096). 19129734 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Mice deficient both in ApoE and in kinin B1 receptor (ApoE(-/-)-B(1)(-/-)) were generated and analyzed for their susceptibility to atherosclerosis and aneurysm development under cholesterol rich-diet (western diet) and angiotensin II infusion. 19618151 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE Angiotensin II and its type 1 receptor (AT1R) are both expressed in the adipose tissue and involved in the genesis of atherosclerosis as well as hypertension. 19696781 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II has been shown to be proinflammatory and to promote atherosclerosis. 19762680 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) is a critical factor in inflammatory responses, which promotes the pathogenesis of atherosclerosis. 20500895 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE The atherosclerosis-enhancing effects of angiotensin II are complex and incompletely understood. 20504763 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes. 20945963 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE To further elucidate the role of COUP-TFII, we performed DNA microarrays in VEC transfected with the siRNA of COUP-TFII and subsequently stimulated with angiotensin II (AngII) and compared the expression profiles of 112 genes involved in various atherosclerosis-related pathways. 21069739 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (Ang II) stimulates vascular smooth muscle cell (VSMC) hypertrophy as a critical event in the development of vascular diseases such as atherosclerosis. 21118843 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Therefore, we hypothesized that Th17 response may play an important role in angiotensin II-induced atherosclerosis. 21292406 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Regulator of G-protein signaling 2 (RGS2) is a key molecule in signal pathways of vasoactive peptides, such as angiotensin II and endothelin 1, and is believed to have an important role in the pathophysiology of atherosclerosis. 21451528 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease CTD_human The purpose of this study was to test the hypothesis that administration of PCB77 to male apolipoprotein E (ApoE) -/- mice promotes AngII-induced atherosclerosis and AAA formation. 21925196 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE During active disease, patients with granulomatosis with polyangiitis (GPA; Wegener's granulomatosis) have accelerated atherosclerosis and ANGII inhibitors are recommended to these patients to reduce atherosclerosis. 21936613 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE However, endothelial-specific Nox2 overexpression did not alter native or angiotensin II-driven atherosclerosis in either the aortic root or the descending aorta. 22287576 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease CTD_human Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. 22539767 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Therapeutic disease RGD Hypertension and atherosclerosis rats were treated with GPE nanoparticles carrying AGT shRNA. 22977667 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population. 23497386 2013
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE In this study, we sought to determine the effect of sRAGE in inhibiting AngII-induced atherosclerosis in apolipoprotein E knockout mice (Apo E KO). 23936343 2013
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Additionally, lncRNAs have been associated with angiotensin II actions and with vascular diseases, including coronary heart disease and atherosclerosis. miRNAs, well studied in various vascular diseases, have also been recently shown to be differentially expressed in the biofluids of patients with vascular disease and mediate cell-cell communication. 24614861 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Previous studies have reported important roles of endothelin-1 (ET-1) and angiotensin II (Ang II) in the pathogenesis of atherosclerosis. 24877885 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). 24942509 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Interestingly, in a model of enhanced vascular inflammation using angiotensin II, P2Y(6) deficiency enhanced formation of aneurysms and exhibited a trend towards increased atherosclerosis in the aorta of LDLR knockout mice. 25360548 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 AlteredExpression disease BEFREE Hypoxia in HCASMCs increases leptin expression through the induction of AngII, ROS, and the JNK pathway to enhance atherosclerosis in HCASMCs. 25573199 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Angiotensin II (AngII) type 1 receptor (AT1R) blockers have been proved to reduce atherosclerosis. 26771341 2016