| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Whether blocking ACAT1 benefits atherosclerosis has been under debate for more than a decade. | 31495784 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The mice transplanted with Acat1-null bone marrow developed severe cutaneous xanthoma, which was filled with numerous macrophages and cholesterol clefts and had markedly increased expression of inflammatory cytokines, and increased atherosclerosis. | 30354239 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Several studies suggest an important role of Acyl-CoA: cholesterol acyltransferase-1(ACAT-1) in the development of atherosclerosis. | 29179498 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Thus, the AS-specific methylation of the three‑gene panel (TIMP1, ABCA1, and ACAT1) may serve as a valuable biomarker for the early detection of AS. | 27082829 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | ACAT catalyzes the formation of cholesteryl esters (CE) in monocytes/macrophages, and it promotes the foam cell formation at the early stage of atherosclerosis. | 19189937 | 2009 | ||||
|
0.080 | Biomarker | disease | BEFREE | K-604, a potent and selective inhibitor of ACAT-1, suppressed the development of atherosclerosis in an animal model without affecting plasma cholesterol levels, providing direct evidence that pharmacological inhibition of ACAT-1 in the arterial walls leads to suppression of atherosclerosis. | 16820149 | 2007 | ||||
|
0.080 | Biomarker | disease | BEFREE | ACAT1 -/- mice have less atherosclerosis than their ACAT1 +/+ counterparts, presumably because of the decreased ACAT activity in the macrophages. | 11264983 | 2001 | ||||
|
0.080 | Biomarker | disease | BEFREE | To determine the role of ACAT-1 in atherogenesis, we crossed the ACAT-1-/- mice with mice lacking apolipoprotein (apo) E or the low density lipoprotein receptor (LDLR), hyperlipidemic models susceptible to atherosclerosis. | 10777503 | 2000 |