Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE Lipoprotein(a) [Lp(a)] is a well-recognized, independent risk factor for atherosclerotic cardiovascular disease, with elevated levels estimated to be prevalent in 20% of the population. 31147269 2020
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE The association between elevated plasma levels of lipoprotein (a) [Lp(a)] and atherosclerotic cardiovascular disease (ASCVD) has been discussed for many years. 30847681 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE The purpose of this review is to highlight our emerging understanding of lipoprotein(a) [Lp(a)]'s role in atherosclerotic cardiovascular disease (ASCVD), its structure-function relationship, and promising developments within the therapeutic pipeline. 31261178 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE A considerable body of data from genetic and epidemiological studies strongly support a causal relationship between high lipoprotein(a) [Lp(a)] levels, and the development of atherosclerosis and cardiovascular disease. 31350625 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Moreover, mice with inherited deficiency in LPA receptor signaling are protected from experimental atherosclerosis. 31533471 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Lipoprotein(a) as an Old and New Causal Risk Factor of Atherosclerotic Cardiovascular Disease. 31061262 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Evaluating the Potential Association Between Lipoprotein(a) and Atherosclerosis (from the Mediators of Atherosclerosis Among South Asians Living in America Cohort). 30626499 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE Nontraditional cardiovascular risk factors such as lipoprotein(a) (Lp(a)), the genetic polymorphisms of apolipoprotein(a), apolipoprotein E (ApoE), and apolipoprotein B (ApoB) increase the prevalence of atherosclerosis in end-stage renal disease (ESRD) through quantitative and qualitative alterations. 31119518 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE There is now significant evidence to support an independent causal role for lipoprotein(a) (Lp(a)) as a risk factor for atherosclerotic cardiovascular disease. 31783529 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE Elevated plasma levels of Lipoprotein(a) [Lp(a)] are recognized as a significant risk factor for atherosclerotic vascular disease. 31340235 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Lipoprotein(a) and other ASCVD risk factors were measured at baseline (1996-1998) in the biracial Atherosclerosis Risk in Communities study; participants without prevalent ASCVD (coronary heart disease or stroke) were monitored ∼15 years for incident ASCVD events. 30685442 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE These findings have implications for new therapies for lowering apolipoprotein(a) and apoB to prevent atherosclerotic cardiovascular disease. 30447089 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE The conventional model of atherosclerosis presumes that the mass of cholesterol within very low-density lipoprotein particles, low-density lipoprotein particles, chylomicron, and lipoprotein (a) particles in plasma is the principal determinant of the mass of cholesterol that will be deposited within the arterial wall and will drive atherogenesis. 31642874 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE Lipoprotein (a) (Lp(a)) is a risk factor for atherosclerosis but its role in IRD with accompanying coronary artery disease (CAD) is still unclear. 31079089 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE Non-high-density (HDL)-cholesterol, low-density lipoprotein (LDL)-particle number, apolipoprotein B, lipoprotein(a) (Lp(a)), and small-dense (sdLDL) and large-buoyant (lbLDL) LDL-subfractions are emerging apo B-containing atherosclerotic cardiovascular disease (ASCVD) risk factors. 31311555 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE While most work has focused on LDL, oxidation of which has long been associated with pro-inflammatory responses and atherosclerosis, some studies on HDL, VLDL and Lipoprotein(a) have also been reported. 30579928 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE The use of transgenic and gene knockout animals, gene manipulated cells, pharmacological LPA receptor agonists and antagonists have provided many insights into the biological significance of LPA and individual LPA receptors in the progression of atherosclerosis and vascular diseases. 31472182 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE Elevated lipoprotein(a) levels are associated with coronary artery calcium scores in asymptomatic individuals with a family history of premature atherosclerotic cardiovascular disease. 29550494 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE Although lipoprotein(a) (Lp(a)) has been regarded as an independent risk factor for atherosclerotic cardiovascular disease (ASCVD), its predictive role in outcomes in stable coronary artery disease (CAD) has been undetermined. 31178022 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Lipoprotein(a) [Lp(a)] may play a causal role in atherosclerosis. 30586750 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE In this study, a cohort of 110 patients with established atherosclerotic cardiovascular disease (ASCVD) due to hypercholesterolemia or concomitant lipoprotein(a)-hyperlipoproteinemia, who received PCSK9 antibodies for the first time during routine care, were consecutively identified. 30817043 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE Interest in lipoprotein (a) [Lp(a)] has exploded over the past decade with the emergence of genetic and epidemiological studies pinpointing elevated levels of this unique lipoprotein as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve disease (CAVD). 30732864 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE LDL-C is unquestionably causal in the development of atherogenesis and atherosclerotic cardiovascular disease, but new options are required to address triglyceride-rich lipoproteins and lipoprotein(a). 31060364 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE Low-density lipoprotein cholesterol (LDL-C) level and lipoprotein(a) [Lp(a)] ≥ 50 mg/dL predict atherosclerotic cardiovascular disease (ASCVD) risk in adults with familial hypercholesterolemia (FH), but their role for children with FH is less clear. 30150142 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE We examined the association of apolipoprotein B (ApoB), small-dense low-density lipoprotein cholesterol (sdLDL-C), lipoprotein (a) (Lp[a]), and lipoprotein-associated phospholipase A<sub>2</sub> (LpPLA<sub>2</sub>) activity with 15-year change in Delayed Word Recall Test, Digit Symbol Substitution Test (DSST), Word Fluency Test (WFT), and overall summary score in 9,350 participants in the Atherosclerosis Risk in Communities study. 31043469 2019