Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE We demonstrated that the increase of sICAM-1, sVCAM-1 and PAI-1, together with decrease of omentin-1 led to a proinflammatory imbalance pointing to the presence of subclinical atherosclerosis, and improving CVD risk stratification in non-smoking patients at early stage MetS beyond traditional scores. 31349950 2019
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE Plasminogen activator inhibitor ( PAI -1) is associated with excessive fibrin accumulation, thrombus formation, and atherosclerosis. 30371230 2018
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 AlteredExpression disease BEFREE The aim of this cross-sectional study was to evaluate the differences in plasma levels of plasminogen activator inhibitor-1 (PAI-1) and of von Willebrand factor (vWF) as endothelial hemostatic markers and carotid intima-media thickness (C-IMT) as a morphologic marker for atherosclerotic vascular disease among dyslipidemic individuals with apoB levels higher, estimated or lower based on regression equation of apoB vs non-HDL-C. 28502501 2018
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE The levels of CLOCK, leukemia inhibitory factor (LIF), intercellular adhesion molecule 1 (ICAM-1), perilipin 2 (ADFP), nuclear factor kappa B (NF-κB), and plasminogen activator inhibitor-1 (PAI-1), as well as the number of atherosclerotic plaques were elevated in the AS mouse model, as compared with the control group. 30124738 2018
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 AlteredExpression disease BEFREE In this study we explored the microRNAs responsible for the regulation of PAI-1 during LPS-stimulated inflammation in human aortic endothelial cells and subsequently studied the effect of a newly synthesized mitochondria-targeted esculetin (Mito-Esc) that was shown for its anti-atherosclerotic potential, in modulating PAI-1 levels and its targeted miRs during angiotensin-II-induced atherosclerosis in ApoE<sup>-/-</sup> mice. 28213977 2018
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 GeneticVariation disease BEFREE Therefore, we performed this study to better assess the relationship between PAI-1 genetic variations and atherosclerosis. 29908999 2018
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE Furthermore, PCB126 exposure in MCD-fed mice led to increased plasma inflammatory markers such as Icam-1, plasminogen activator inhibitor-1 and proatherogenic trimethylamine-N-oxide, suggesting inflammation of the peripheral vasculature that is characteristic of atherosclerosis. 28973532 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE Interleukin-6 and plasminogen activator inhibitor-1 did not provide incremental value to fibrinogen when examining the associations with degree of atherosclerosis. 27755007 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE Finally, we explored the causal effect of PAI-1 on cardiovascular risk factors including metabolic and subclinical atherosclerosis measures. 28550093 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE Plasminogen activator inhibitor-1 (PAI-1) has been regarded as a risk factor for thrombosis and atherosclerosis. 29253845 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 GeneticVariation disease BEFREE Association of plasminogen activator inhibitor-1 and low-density lipoprotein heterogeneity as a risk factor of atherosclerotic cardiovascular disease with triglyceride metabolic disorder: a pilot cross-sectional study. 28692480 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 GeneticVariation disease BEFREE In this patient, without traditional risk factors for atherosclerosis, eight mutations and polymorphisms in six different genes were identified: polymorphism of factor V Leiden (1691 GA), factor II prothrombin (20210 GA), methylenetetrahydrofolate reductase (MTHFR, 677 CT and 1298 AC), plasminogen activator inhibitor 1 (PAI-1) polymorphism 4G/5G and glycoprotein VI (GP6, 13254 TC, Ser219Pro). 28382527 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE PAI-1 has been linked to fibrin deposition that evolves into organ fibrosis and atherosclerosis. 28785222 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 AlteredExpression disease BEFREE Plasma PAI-1 levels and 4G/4G genotype frequency were significantly higher in the severe atheromatosis group compared to the other groups (p<0.001). 22011808 2011
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 GeneticVariation disease BEFREE In this study, we aimed to investigate the effect of tPA (tissue plasminogen activator) and PAI-1 (plasminogen activator inhibitor) antigen concentrations and 4G/5G polymorphism of the PAI-1 gene on the development of atherosclerosis in SLE patients. 21719525 2011
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE Plasminogen activator inhibitor type-1 (PAI-1) has already been associated with atherosclerosis; myocardial infarction; and cardiovascular disease risk factors such as obesity, insulin resistance, and dyslipidemia. 20127289 2010
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 AlteredExpression disease BEFREE We tested the hypothesis that leptin induces PAI-1 and inhibits tPA expression using human coronary artery endothelial cells (HCAEC) in culture as these cells play an important role in atherosclerosis. 20051227 2010
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE PAI-1 is paracrine secretion of pro- and antiinflammatory cytokines, thereby playing a possible role in the adiposity-related inflammation and atherosclerosis. 19033264 2009
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE The results indicate that ghrelin inhibits both basal and TNF-alpha-induced PAI-1 production via NF-kappaB pathway in HepG2 cells, and suggest that the peptide plays a therapeutic role in atherosclerosis, especially in obese patients with insulin resistance, in whom ghrelin levels were reduced. 18700166 2008
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE Negative correlations between antioxidative defense parameters and BMI, abdominal obesity, insulin secretion, systolic blood pressure and atherogenic lipid factors, as well as correlations between PAI-1 and insulin resistance and basal glycemia in the metabolic syndrome group contribute to accelerated atherosclerosis. 17848118 2007
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE The effect of PAI-1 upon angiogenesis is also involved in atherosclerosis, in which high levels of PAI-1 expression are observed. 17509745 2007
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 AlteredExpression disease LHGDN Elevated plasma PAI-1 activity was independently associated with coronary microvascular dysfunction, which suggests that plasma PAI-1 activity is an important clue linking hypofibrinolysis to the development of atherosclerosis. 17322633 2007
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease BEFREE Plasminogen activator inhibitor type 1 (PAI-1) is a major physiologic regulator of the fibrinolytic system and has recently gained recognition as a modulator of inflammation and atherosclerosis. 16968709 2006
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 AlteredExpression disease BEFREE In conclusion, obesity and TNF-alpha up-regulation of PAI-1 expression in human hepatocytes may contribute to the impairment of the fibrinolytic system, leading to the development of atherosclerosis and liver fibrosis in insulin-resistant individuals. 17046548 2006
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.400 Biomarker disease LHGDN Studies with transgenic mice have revealed a functional role for PAI-1 in wound healing, atherosclerosis, metabolic disturbances such as obesity and insulin resistance, tumor angiogenesis, chronic stress, bone remodeling, asthma, rheumatoid arthritis, fibrosis, glomerulonephritis and sepsis. 15634264 2005