Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | The expression of ECM, including collage type 3, α1 (Col‑3A1), matrix metalloproteinase (MMP)‑2/-9 and transforming growth factor (TGF)‑β was higher in patients with permanent AF, compared with patients in sinus rhythm (SR), and the expression levels of MIF were also increased in AF. | 29257298 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | The index of low SIRT1 and high MMP2 respectively correlated with patients history of MI (ρ=0.3, p=0.01) and marginally with presence or history of atrial fibrillation (AF) (ρ=0.213, p=0.076). | 28043667 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | MMP-2 may be involved in the development of AF through promoting BAX expressions and inhibiting Bcl-2. | 27141955 | 2016 | ||||
|
0.070 | Biomarker | disease | BEFREE | This upregulated expression and activity were positively correlated with higher regulatory indicators of atrial structural remodeling as reflected by higher transcripts of tumor necrosis factor (TNF)-related apoptosis-inducing ligand, matrix metalloproteinase (MMP)-2 and MMP-9, pro-inflammatory factors TNF-α and interleukin-6, and higher ratios of MMP-9/tissue inhibitor of metalloproteinase (TIMP)-1 and MMP-2/TIMP-2 in AF. | 22001292 | 2011 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | No relationship was found in this cohort between the presence of the MMP-2 -1306C>T and -735C>T polymorphism and AF. | 20138860 | 2010 | ||||
|
0.070 | Biomarker | disease | BEFREE | 2) Bisphosphonates are associated with atrial fibrillation, and MMP2 is the only gene known to be associated with both bone abnormalities and atrial fibrillation. | 19070762 | 2009 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | The T allele of the MMP2 polymorphism and the C allele of the IL10 polymorphism were a risk factor for and protective factor against AF, respectively. | 17487426 | 2007 |