Source: CURATED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 10716
Gene Symbol: TBR1
TBR1
0.650 Biomarker disease CTD_human
Entrez Id: 50944
Gene Symbol: SHANK1
SHANK1
0.530 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 55217
Gene Symbol: TMLHE
TMLHE
0.460 Biomarker disease CTD_human
Entrez Id: 6638
Gene Symbol: SNRPN
SNRPN
0.410 Biomarker disease CTD_human
Entrez Id: 1977
Gene Symbol: EIF4E
EIF4E
0.320 Biomarker disease CTD_human
Entrez Id: 9379
Gene Symbol: NRXN2
NRXN2
0.320 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 4929
Gene Symbol: NR4A2
NR4A2
0.300 Biomarker disease GENOMICS_ENGLAND [Transudative bile peritonitis in the elderly]. 516625 1979
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.320 Biomarker disease CTD_human However, we report a positive association between autism and the locus containing the gene for HRAS-1. 8098541 1993
Entrez Id: 324
Gene Symbol: APC
APC
0.310 Biomarker disease CTD_human Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion. 8071957 1994
Entrez Id: 4163
Gene Symbol: MCC
MCC
0.300 Biomarker disease CTD_human Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion. 8071957 1994
Entrez Id: 551
Gene Symbol: AVP
AVP
0.400 Biomarker disease CTD_human Low-dose naltrexone effects on plasma chemistries and clinical symptoms in autism: a double-blind, placebo-controlled study. 8570775 1995
Entrez Id: 5443
Gene Symbol: POMC
POMC
0.340 Biomarker disease CTD_human These results suggest a possible linkage between abnormal plasma chemistries, especially those related to the pro-opiomelanocortin system, and autistic symptoms. 8570775 1995
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.390 Biomarker disease CTD_human Since autoimmune response involves immune activation, the plasma levels of interferon-alpha (IFN-alpha), interferon-gamma (IFN-gamma), interleukin-12 (IL-12), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and soluble intercellular adhesion molecule-1 (sICAM-1) were measured in autistic patients and age-matched normal controls. 8964908 1996
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.350 Biomarker disease CTD_human Strong association of the third hypervariable region of HLA-DR beta 1 with autism. 8765331 1996
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.400 Biomarker disease CTD_human Evidence of linkage between the serotonin transporter and autistic disorder. 9152989 1997
Entrez Id: 2332
Gene Symbol: FMR1
FMR1
0.500 Biomarker disease CTD_human Both the normal subjects and the patients with autism have 53 CGG repeats in FMR1, and the majority have two interspersed AGG. 9806479 1998
Entrez Id: 2562
Gene Symbol: GABRB3
GABRB3
0.400 Biomarker disease CTD_human The convergence of GABRB3 as a positional and functional candidate along with the linkage-disequilibrium data suggests the need for further investigation of the role of GABRB3 or adjacent genes in autistic disorder. 9545402 1998
Entrez Id: 7508
Gene Symbol: XPC
XPC
0.300 Biomarker disease CTD_human Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia. 9804340 1998
Entrez Id: 3198
Gene Symbol: HOXA1
HOXA1
0.390 Biomarker disease CTD_human Mice with null mutations of Hoxa1 or Hoxb1, two genes critical to hindbrain development, have phenotypic features frequently observed in autism, but no naturally occurring variants of either gene have been identified in mammals. 11091361 2000
Entrez Id: 7337
Gene Symbol: UBE3A
UBE3A
0.500 Biomarker disease CTD_human We have screened the families of the Collaborative Linkage Study of Autism for several markers spanning a candidate region covering approximately 2 Mb and including the Angelman syndrome gene (UBE3A) and a cluster of gamma-aminobutyric acid (GABA(A)) receptor subunit genes (GABRB3, GABRA5, and GABRG3). 11543639 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker disease CTD_human We review the scanty literature data on the association of Cowden syndrome and autism and emphasize that the association of progressive macrocephaly and pervasive developmental disorder seems to be an indication for screening for PTEN mutations. 11496368 2001
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease CTD_human Our findings suggest that longer triplet repeats in the 5'UTR of the RELN gene confer vulnerability to autistic disorder. 11317216 2001
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease CTD_human Quantification of Reelin bands showed 43%, 44%, and 44% reductions in autistic cerebellum (mean optical density +/- SD per 30 microg protein 4.05 +/- 4.0, 1.98 +/- 2.0, 13.88 +/- 11.9 for 410 kDa, 330 kDa, and 180 kDa bands, respectively; N = 5) compared with controls (mean optical density +/- SD per 30 microg protein, 7.1 +/- 1.6, 3.5 +/- 1.0, 24.7 +/- 5.0; N = 8, p < 0.0402 for 180 kDa band). 11814262 2001
Entrez Id: 7472
Gene Symbol: WNT2
WNT2
0.370 Biomarker disease CTD_human Based on these findings, we hypothesize that rare mutations occur in the WNT2 gene that significantly increase susceptibility to autism even when present in single copies, while a more common WNT2 allele (or alleles) not yet identified may exist that contributes to the disorder to a lesser degree. 11449391 2001