Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality. 31302032 2019
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE 2p16.3 deletions, involving heterozygous NEUREXIN1 (NRXN1) deletion, dramatically increase the risk of developing neurodevelopmental disorders, including autism and schizophrenia. 31812984 2019
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 Biomarker disease BEFREE Rats with impaired social guidance of behavior due to knockout of Nrxn1, an analog of autism-associated gene NRXN, exhibited marked LA-MeA deficits. 28114293 2017
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 Biomarker disease BEFREE Heterozygous mutations of the NRXN1 gene, which encodes the presynaptic cell-adhesion molecule neurexin-1, were repeatedly associated with autism and schizophrenia. 26279266 2015
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Deletions and point mutations in the neurexin 1 (NRXN1) gene are associated with a broad spectrum of neuropsychiatric and neurodevelopmental disorders, including autism, intellectual disability, epilepsy, developmental delay, and schizophrenia. 24633560 2014
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 Biomarker disease BEFREE Our cases expand the phenotype of biallelic α NRXN 1 mutations and emphasize the important role of NRXN1 in autism and intellectual disability. 25149956 2014
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Rare variants analysis of neurexin-1β in autism reveals a novel start codon mutation affecting protein levels at synapses. 24064682 2013
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Here, we identified deletions of the NRXN1 region in affected cohorts, confirming a strong association with the autism spectrum and other neurodevelopmental disorders. 23472757 2013
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Exonic deletions in NRXN1 have been associated with several neurodevelopmental disorders, including autism, schizophrenia and developmental delay. 23536886 2013
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Deletions at 2p16.3 involving exons of NRXN1 are associated with susceptibility for autism and schizophrenia, and similar deletions have been identified in individuals with developmental delay and dysmorphic features. 23495017 2013
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 Biomarker disease BEFREE Previous analyses of neurexin 1α (Nrxn1α) knockout (KO) mouse as a model of these disorders have revealed impairments in synaptic transmission but failed to reveal defects in social behaviour, one of the core symptoms of autism. 23840597 2013
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 AlteredExpression disease BEFREE Mutations affecting synaptic levels of neurexin-1β in autism and mental retardation. 22504536 2012
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Mutations in neurexin 1 (NRXN1) as well as two other members of the neuroligin family, NLGN3 and NLGN4, have been associated with autism and mutations in NLGN4 have also been associated with intellectual disability, seizures, and EEG abnormalities. 22106001 2012
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Interestingly, there was a statistically significant association of neurexin-1 SNP P300P (rs2303298) with risk of autism (26.2% vs. 13.8%; χ(2) = 22.487; p = 3.45E-006; OR = 2.152 (1.559-2.970)). 22405623 2012
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Sequence variants in NRXN1 are associated with differences in cognition, and with schizophrenia and autism. 22832527 2011
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE A 10.46 Mb 12p11.1-12.1 interstitial deletion coincident with a 0.19 Mb NRXN1 deletion detected by array CGH in a girl with scoliosis and autism. 21626680 2011
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE The breakpoint at 2p was within the NRXN1 gene that has previously been associated with autism, intellectual disabilities, and psychiatric disorders. 21739571 2011
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 Biomarker disease CTD_human At a gene level, CAM genes associated in all three samples (NRXN1 and CNTNAP2), which were previously implicated in specific language disorder, autism and schizophrenia. 20157312 2011
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Three additional subjects with NRXN1 deletions and autism were identified through the Homozygosity Mapping Collaborative for Autism, and this deletion segregated with the phenotype. 20468056 2010
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE We provide support for three previous findings in schizophrenia, as we identified one deletion in a case at 1q21.1, one deletion within NRXN1, and four duplications in cases and one in a control subject at 16p13.1, a locus first implicated in autism and later in schizophrenia. 19880096 2010
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease BEFREE Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. 18945720 2009
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease LHGDN Neurexin 1alpha structural variants associated with autism. 18490107 2008
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 Biomarker disease CTD_human Identifying autism loci and genes by tracing recent shared ancestry. 18621663 2008
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 GeneticVariation disease LHGDN Disruption of neurexin 1 associated with autism spectrum disorder. 18179900 2008
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
0.700 Biomarker disease CTD_human A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha. 18057082 2008