|
TNFRSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
In spite of its limitations, our study details the intersection of systemic autoimmunity and CVID and provides valuable insights into these two groups of disorders.
|
29599028 |
2018 |
|
TNFRSF13B
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CVID carrying biallelic-mutations had a low prevalence of autoimmunity in comparison with TACI wild-type CVID.
|
27123465 |
2016 |
|
TNFRSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.
|
25505277 |
2015 |
|
TNFRSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, compared with TA-Fc, 814-Fc showed two-fold inhibition effect on BLyS binding to TACI, suggesting that 814-Fc could inhibit BLyS bioactivity significantly and might serve as a potential antagonist to treat autoimmune diseases associated with BLyS overexpression.
|
25533501 |
2015 |
|
TNFRSF13B
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Heterozygous C104R or A181E TNF receptor superfamily member 13b (TNFRSF13B) mutations impair removal of autoreactive B cells, weaken B-cell activation, and convey to patients with common variable immune deficiency (CVID) an increased risk for autoimmunity.
|
26100089 |
2015 |
|
TNFRSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
The impact of these abnormalities on T and B cell interaction may not only explain the immunodeficiency but also the development of autoimmunity in select groups of patients with CVID.
|
24747700 |
2014 |
|
TNFRSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
We aimed to focus on the state of the art of the relationship between infections, inflammation and autoimmunity in CVID.
|
23219764 |
2013 |
|
TNFRSF13B
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Heterozygous mutations in the gene encoding the tumor necrosis factor receptor superfamily member TACI are associated with CVID and autoimmune manifestations, whereas two mutated alleles prevent autoimmunity.
|
24051380 |
2013 |
|
TNFRSF13B
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our data suggest a different impact of TACI mutations, from hypogammaglobulinemia in children to autoimmune disease in adulthood.
|
22697072 |
2012 |
|
TNFRSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) mutations seem to be associated with autoimmunity and common variable immunodeficiency in humans.
|
21850030 |
2012 |
|
TNFRSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Although signs of autoimmunity and lymphoproliferation are evident, the human phenotype differs from that of the Tnfrsf13b-/- mouse model.
|
16007087 |
2005 |
|
TNFRSF13B
|
0.100 |
Biomarker
|
group |
BEFREE |
Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor.
|
12594954 |
2003 |
|
TNFRSF13B
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The distribution of cases within families was compatible with autosomal recessive inheritance, making it plausible to test hypotheses about the disease risk of heterozygote carriers of putative CVID genes by comparing the frequency of autoimmune disorders and cancer in 1033 adult blood relatives to that in 566 spouse controls.
|
3957001 |
1986 |