|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
HLA DQA1*05 and DQB1*02 alleles encoding the DQ2.5 molecule and HLA DQA1*03 and DQB1*03 alleles encoding DQ8 molecules are strongly associated with celiac disease (CD) and type 1 diabetes (T1D), two common autoimmune diseases (AD).
|
31331105 |
2019 |
|
HLA-DQA1
|
0.100 |
Biomarker
|
group |
BEFREE |
Association with the HLA DQB1*06:02/DQA1*01:02 (98% vs. 25%) heterodimer (DQ0602), T cell receptors (TCR) and other immune loci suggest autoimmunity but autoantigens are unknown.
|
30541895 |
2018 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In patients with LADA similarly to type 1 genotype DQA1*0301 seems to CONFER susceptibility to thyroid autoimmunity, and DQB1*0201 to celiac disease.
|
26884287 |
2016 |
|
HLA-DQA1
|
0.100 |
Biomarker
|
group |
BEFREE |
All mentioned SNPs are located within the major histocompatibility complex (MHC) region of chromosome 6 and near genes of known immune functions or associations with other autoimmune diseases such as HLA-DQ alpha chain 1 (HLA-DQA1), MICA, MICB, MSH5, TRIM39 and RPP21.
|
25827949 |
2015 |
|
HLA-DQA1
|
0.100 |
Biomarker
|
group |
BEFREE |
Among the genes differentially expressed in female KD patients we identified: HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity; BMP5 and BMP7, involved in cardiomyocyte differentiation defect; and ADAMTS 8, CCL23, and TNFSF15, implicated in anti-angiogenic activities.
|
24384427 |
2014 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
It is likely that combinations of DQA1 and DQB1 alleles are the real culprits of the progression towards multiple autoimmune diseases and HLA-DQ genomic typing will improve the capability to predict associated autoimmune diseases in infancy.
|
22686660 |
2012 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recent evidence from other autoimmune diseases has suggested that class I-encoded HLA-A and HLA-B gene variants confer HLA-DRB1-DQA1-DQB1-independent effects on disease.
|
21816777 |
2011 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We have identified a large Bedouin kindred in which a high prevalence of islet autoimmunity is associated with two different DR3 haplotypes, one carrying the usual DQ2 and the other carrying DQA1*0102-DQB1*0502 (DQ5).
|
17728790 |
2007 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Ancestral haplotype (AH) 8.1(HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases.
|
17911430 |
2007 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The development of MS is influenced by environmental factors, particularly the Epstein-Barr virus (EBV), and genetic factors, which include specific HLA types, particularly DRB1*1501-DQA1*0102-DQB1*0602, and a predisposition to autoimmunity in general.
|
17547851 |
2007 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, this study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.
|
17182961 |
2006 |
|
HLA-DQA1
|
0.100 |
Biomarker
|
group |
BEFREE |
It is noteworthy that certain genes and haplotypes, notably HLA-DRB1*0301, DQA1*0501, DQB1*0201 in Caucasians and DRB1*0405, DQA1*03, DQB1*0401 in Asians, as well as PTPN22, seem to be associated with a variety of autoimmune diseases.
|
16890892 |
2006 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.
|
16879749 |
2006 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
HLA-DQ8 transgenic IAb knockout NOD mice (NOD.DQ8/Ab(0); DQA1*0301, DQB1*0302) develop spontaneous anticardiomyocyte autoimmunity with pathology very similar to human IDCM, but why the heart is targeted is unknown.
|
16751419 |
2006 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These data suggest that HLA-DQA1 alleles do not appear to play a role in the persistence of microchimerism in the peripheral blood or T lymphocytes of patients with selected autoimmune diseases or in healthy individuals.
|
13130476 |
2003 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
LHGDN |
These data suggest that HLA-DQA1 alleles do not appear to play a role in the persistence of microchimerism in the peripheral blood or T lymphocytes of patients with selected autoimmune diseases or in healthy individuals.
|
13130476 |
2003 |
|
HLA-DQA1
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, our data imply that the allele DQA1*0301 is a marker of increased risk for further APS manifestations in patients who suffer from an organ-specific autoimmune disease.
|
12734793 |
2003 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Particularly, the association in all Caucasian populations of an impressive number of autoimmune diseases with genes from the HLA-B8,DR3 haplotype that is part of the ancestral haplotype (AH) 8.1 HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201 has been reported by different research groups.
|
12849055 |
2002 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, GADA but not IA2A indicate the presence of thyrogastric autoimmunity in type 1 diabetes. aTPO have a female preponderance, PCA are weakly associated with HLA DQA1*0501-DQB1*0301 and EmA-IgA + with HLA DQA1*0501-DQB1*0201.
|
11703366 |
2001 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although HLA-DRB1 and -DQA1 alleles have been associated with adult and juvenile idiopathic inflammatory myopathies (JIIM), they only partially account for the genetic risk for these autoimmune disorders.
|
10886238 |
2000 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Screening for gastric autoimmunity is particularly advised in patients who are positive for GADA and for the HLA DQA1*0501-DQB1*0301 haplotype.
|
11073185 |
2000 |
|
HLA-DQA1
|
0.100 |
Biomarker
|
group |
BEFREE |
Cutting edge: persistent fetal microchimerism in T lymphocytes is associated with HLA-DQA1*0501: implications in autoimmunity.
|
10820227 |
2000 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Inducible differential expression of HLA-DQA1 alleles may account for the discordance in the outcome of autoimmune disease in monozygotic twins and HLA-identical siblings.
|
9209509 |
1997 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The finding that alleles of the DQA1 gene differ in promoter strength and responsiveness to TNFalpha suggests a mechanism for the association of certain alleles of this gene with susceptibility to autoimmune disease.
|
8995182 |
1997 |
|
HLA-DQA1
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Type 1 diabetes mellitus (IDDM) is an autoimmune disorder in which the alleles HLA DQA1*0501-DQB1*0201 and DQA1*0301-DQB1*0302 confer strong susceptibility.
|
9226129 |
1997 |