Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 AlteredExpression group BEFREE One biological consequence of reduced IL-4 levels may be increased risk of autoimmunity. 31756521 2020
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity. 31552021 2019
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE However, the effect of IL-4 on basophils themselves, which are emerging as relevant players in allergic as well as autoimmune diseases, was only scarcely addressed so far. 29915306 2018
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE These results suggest the essential role of IL-4 in supporting Treg-mediated immune suppression, which may benefit the development of therapeutic strategies for autoimmune diseases. 29184551 2017
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 GeneticVariation group BEFREE Relationship between the IL-4 gene promoter -590C/T (rs2243250) polymorphism and susceptibility to autoimmune diseases: a meta-analysis. 24628947 2015
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. 25646481 2015
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE In previous studies genes encoding Angiotensin-Converting Enzyme (ACE) and IL-4 (Interleukin-4) were found to be associated with rheumatologic and autoimmune diseases. 24680475 2014
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE HaCat cells were treated with IL-4 at various concentrations for 24h, and PCR gene array on inflammation/autoimmunity was performed three times for analysis of differential gene expression. 23207180 2013
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease in which interleukin-4 (IL-4) plays an important role. 23394902 2013
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 GeneticVariation group BEFREE IL-4 gene -590T/C polymorphism has been shown to be associated with different autoimmune diseases and cancers. 22142023 2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE Taken together, this study sheds new light on the role of posttranslational modification of c-Maf in IL-4 production and Th cell-mediated autoimmune diseases. 22798672 2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 GeneticVariation group BEFREE Data from other studies show that the -589T/C polymorphism in IL-4 promoter may alter IL-4 expression and susceptibility of inflammatory or autoimmune diseases. 21460743 2011
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE These CD4(+)IFN-gamma(high)IL-4(low)IL-10(low)TGF-beta(low)FOXp3(-) cells in fact function as antigen-specific regulatory cells that restrain the development of autoimmunity by increasing the threshold of Th17 activation. 20382706 2010
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group CTD_human Therefore, the attenuated autoimmunity following loss of IL-4 and IL-6 is dose-dependent, as higher doses of Hg are able to override the attenuation observed using lower doses. 19077085 2009
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 GeneticVariation group BEFREE Factor VIII gene mutations and genetic polymorphisms of the IL1beta, IL4, and IL10 genes, known to influence antibody production in autoimmune diseases, were analyzed in 164 patients (124 with severe, 26 with moderate, and 14 with mild disease) in 78 unrelated families with hemophilia A. Seventy-seven (47%) patients in 54 families had a history of inhibitors (57 high responding, 20 low responding). 16380445 2006
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE Reactive oxygen species in the initiation of IL-4 driven autoimmunity as a potential therapeutic target. 15032693 2004
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 GeneticVariation group BEFREE Associations have been reported between single nucleotide polymorphisms (SNPs) of IL-10 and the Ile50Val polymorphism of the IL-4 receptor gene (IL-4R) gene and atopy and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. 15497451 2004
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE In contrast, IL-4 appears to be involved in the differentiation of AChR-specific regulatory CD4(+) T cells, which can prevent the development of EAMG and its progression to a self-maintaining, chronic autoimmune disease. 14592887 2003
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE We observed a simultaneous increase in IL-4 and IFNgamma secretion in early islet autoimmunity of Ab+ subjects, but not in insulin-treated T1D patients. 14679078 2003
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE Thus, IL-4 may serve multiple roles in the development of lupus: it may enhance autoantibody production via its direct B-cell effects, protect against autoimmunity via its T-cell suppressor effect, or perpetuate tissue damage via its direct effects on target organs. 12921752 2003
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE Previous studies have suggested a role for interleukin-4 gene (IL4) in susceptibility to multiple sclerosis (MS) as well as other autoimmune diseases. 12667657 2003
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE IL-4 acts at the locus of the dendritic cell to decrease the cytolytic T-cell response, preventing autoimmunity. 11175852 2001
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 GeneticVariation group BEFREE This variation in the IL-4 gene may provide further clues to the pathogenesis of autoimmune thyroid disease and other organ-specific autoimmune diseases. 10843185 2000
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group BEFREE The bias toward an IL-4-dominant response in BALB/c mice protects mice from severe Lyme-induced arthritis and spontaneous autoimmune disease. 10553063 1999
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.400 Biomarker group CTD_human Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains. 8898950 1996