| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | GeneticVariation | group | BEFREE | Although several studies have investigated the association between C4, C4A, and C4B gene copy number variations (CNVs) and susceptibility to autoimmune diseases, the results remain inconsistency for those diseases. | 28205620 | 2017 | ||||
|
0.360 | Biomarker | group | BEFREE | Genetic variants resulting in non-expression of complement C4A and C4B genes are common in healthy European populations and have shown association with a number of diseases, most notably the autoimmune disease, systemic lupus erythematosus. | 21857912 | 2011 | ||||
|
0.360 | Biomarker | group | CTD_human | The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children. | 20452682 | 2010 | ||||
|
0.360 | GeneticVariation | group | BEFREE | The monomodular-short haplotype with a single C4B gene and the absence of C4A, which is in linkage-disequilibrium with HLA DRB1*0301 in Europeans and a strong risk factor for autoimmune diseases, has a frequency of 0.012 in AIA but 0.106 among healthy European Americans (p=6.6x10(-8)). | 19135723 | 2009 | ||||
|
0.360 | GeneticVariation | group | LHGDN | Applications of these vigorously tested techniques may clarify the roles that human C4A and C4B gene-dosage variations play in infectious and autoimmune diseases. | 12224044 | 2002 | ||||
|
0.360 | Biomarker | group | BEFREE | These patients probably carried all, or at least the class II and III regions, of the extended haplotype marked by B8/C4A*Q0/C4B1/BfS/DR3/DR52, which has been associated with several autoimmune diseases and is present in 11% of the healthy caucasoid population. | 7923882 | 1994 | ||||
|
0.360 | Biomarker | group | BEFREE | It is probable that while interaction between certain HLA-DR3 and DR4-containing supratypes is important in conferring susceptibility to Type 1 diabetes, other manifestations of autoimmunity are associated with supratypes containing C4AQ0, and in particular the diabetogenic supratype HLA-B8-C4AQ0-C4B1-BfS-DR3. | 6332753 | 1984 |