Down-regulation of miR-188-3p by reducing histone acetylation up-regulated MLH1 expression and contributed to promotion of apoptosis in spermatogenic cells, in patients with azoospermia.
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, rs2075789;rs864622096;587781908;rs786203623;rs587781908;rs1248142939;s587781908" genes_norm="4292;4439;5395">Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.