Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.090 Biomarker group BEFREE Finally, we revealed that agmatine diminishes IL-8 production by airway epithelial cells in response to bacterial infection, with a consequent decrease in neutrophil recruitment to the murine airways in an acute pneumonia model. 30688634 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.090 Biomarker group BEFREE IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p < 0.0001), neutrophils (p < 0.0001) and NE activity (p < 0.01 and p < 0.001). 29884450 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.090 AlteredExpression group BEFREE These results show that IL-8 overexpression in the bronchial epithelium benefits lung immunity to bacterial infection, but specifically drives lung damage through persistent inflammation, lung remodeling, and damaged tight junctions, leading to impaired lung function. 29894204 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.090 Biomarker group BEFREE An excessive neutrophilic inflammation, mainly orchestrated by the release of IL-8 from bronchial epithelial cells and amplified by chronic bacterial infection with Pseudomonas aeruginosa, leads to progressive tissue destruction. 21411730 2011
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.090 AlteredExpression group LHGDN Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. 18678662 2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.090 Biomarker group BEFREE These results indicate that S. aureus can down-regulate IL-8 release in endothelial cells through the secretion of inhibitory factor(s), and this may result in decreased neutrophil recruitment, thus interfering with the host immune response to bacterial infection. 17177974 2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.090 Biomarker group LHGDN In summary, we describe a signaling pathway, Duox1-TACE-TGF-alpha-EGFR, on the surface of airway epithelial (NCI-H292) cells that mediates airway epithelial defense against bacterial infection by producing IL-8. 17220369 2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.090 AlteredExpression group LHGDN Elevated urine IL-8 level in kidney transplant patients with asymptomatic bacteriuria may reflect impaired immune response to bacterial infection and occult inflammatory process in urinary tract. 16794530 2006
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.090 Biomarker group BEFREE The possible role of the proinflammatory cytokines interleukin (IL)-1, tumor necrosis factor-alpha, IL-6, and IL-8 as modulators of host resistance to bacterial infections is discussed. 9917883 1998