| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | group | BEFREE | Patients with leukocyte adhesion deficiency type 1 (LAD1) suffer from life-threatening bacterial infections due to mutations in the common β<sub>2</sub> integrin subunit (CD18/ITGB2 gene). | 31200085 | 2019 | ||||
|
0.070 | Biomarker | group | BEFREE | Employing classically activated (M1) and alternatively activated (M2) murine bone-marrow-derived macrophage (BMDMø), we observed that immunologic activation of macrophages before P. gingivalis challenge dictated phenotype-specific changes in the expression of inflammation-associated molecules important to sensing and tuning host response to bacterial infection including Toll-like receptors 2 and 4, CD14, CD18 and CD11b (together comprising CR3), major histocompatibility complex class II, CD80, and CD86. | 27346827 | 2017 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Leukocyte adhesion deficiency type I (LAD-I) is a primary immunodeficiency caused by mutations in the ITGB2 gene and is characterized by recurrent and life-threatening bacterial infections. | 27056660 | 2016 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Children with leukocyte adhesion deficiency type 1 (LAD-1) and dogs with canine LAD (CLAD) develop life-threatening bacterial infections due to mutations in the leukocyte integrin CD18. | 21275758 | 2011 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Mice deficient in CD18, which lack all four CD11 integrins, have leukocytosis and increased susceptibility to bacterial infection. | 11390487 | 2001 | ||||
|
0.070 | Biomarker | group | BEFREE | Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1. | 3899217 | 1985 | ||||
|
0.070 | Biomarker | group | BEFREE | Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections. | 3156928 | 1985 |