Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 Biomarker group BEFREE In summary, our findings reveal that miR-203 in fish is a critical suppressor of innate immune responses to bacterial infection by suppressing a feedback to IRAK4-NF-κB-mediated signaling. 29242191 2018
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 Biomarker group BEFREE Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in innate immune signaling by Toll-like receptors (TLRs), and loss of IRAK4 activity in mice and humans increases susceptibility to bacterial infections and causes defects in TLR and IL1 ligand sensing. 28924041 2017
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 Biomarker group BEFREE In these studies, mice homozygous for a mutant IRAK4 that lacks kinase activity (IRAK4(KDKI)) were used to address the role of IRAK4 in response to TLR agonists or bacterial infection. 23209321 2013
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 GeneticVariation group BEFREE Autosomal recessive IRAK-4 and MyD88 deficiencies predispose affected patients to recurrent invasive pyogenic bacterial infection. 21734245 2011
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 GeneticVariation group BEFREE Mutations in IRAK4 selectively impair TLRs other than TLR3 and most IL-1R responses, and confer a predisposition to pyogenic bacterial diseases, including invasive pneumococcal disease in particular. 18083507 2008
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 GeneticVariation group BEFREE Activating mutations in TGFB1, TGFBR1, and TGFBR2 (Camurati-Engelmann disease and Marfan-like syndromes) and loss-of-function mutations in IRAK4 and MYD88 (Mendelian predisposition to pyogenic bacterial infections) had no detectable impact. 18591412 2008
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 Biomarker group BEFREE Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. 17893200 2007
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 AlteredExpression group LHGDN Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex. 15905496 2005
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 Biomarker group BEFREE Inherited interleukin-1-receptor-associated kinase-4 (IRAK-4) deficiency is a recently described immunodeficiency associated with pyogenic bacterial infections and a poor inflammatory response. 15825022 2005
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 AlteredExpression group BEFREE Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex. 15905496 2005
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 GeneticVariation group BEFREE Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. 12925671 2003
Entrez Id: 51135
Gene Symbol: IRAK4
IRAK4
0.100 GeneticVariation group LHGDN Pyogenic bacterial infections in humans with IRAK-4 deficiency. 12637671 2003