Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE TLR2, is also the initial barrier against bacterial infection and plays an important role in recognising a variety of bacterial lipoproteins. 29457581 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE Lipoteichoic acid (LTA) and lipoproteins are representative TLR2 ligands that play important roles in bacterial infection and in host inflammatory responses. 30176521 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE In this study, we focused on the pathways regulating immune responses in murine macrophages and modeled post viral-bacterial infections through pretreatment of bone marrow-derived macrophages (BMDMs) with a toll-like receptor (TLR) 7/8 ligand (R848) and subsequent challenge with TLR2/4 agonists to mimic bacterial infection. 29515583 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 AlteredExpression group BEFREE Our results confirmed pro-inflammatory function of extracellular Hsp70, and suggest its possible implication in COPD exacerbations caused by bacterial infection through desensitization or inappropriate activation of TLR2 and TLR4 receptors. 29067554 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE There was also a moderate positive correlation between the expression Myd88-Tnfrsf11 and Tlr2-Myd88, suggesting the relevance of Tlr2-Myd88 in bone loss due to bacterial infection. 29995146 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE We therefore examined a bacterial infection scenario involving co-stimulation of TLR4 and TLR2. 28380352 2017
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 AlteredExpression group BEFREE This early response to viral capsids required the cell surface-expressed PRR TLR2 and allowed for improved clearance of subsequent bacterial infection that commonly complicates respiratory viral infections. 29138299 2017
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE TLR2 recognizes bacterial lipoproteins and plays a central role in the host defense against bacterial infections, including those caused by Staphylococcus aureus. 28858870 2017
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 AlteredExpression group BEFREE Moreover, we observed that expression of TLR2 and TLR4 was significantly higher in patients with AML and bacterial infection in comparison with group with separate fungal infection (ΔCt TLR2 1.15 ± 1.06 vs 0.66 ± 0.51 and ΔCt TLR4 0.45 ± 0.38 vs 0.21 ± 0.19). 25412934 2014
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE Impaired airway innate immunity (e.g., suppressed Toll-like receptor 2 [TLR2] signaling) has been reported in allergic lungs with bacterial infection. 21892915 2011
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE Our findings may offer a deliverable approach to attenuate bacterial infections in airways of asthma or chronic obstructive pulmonary disease patients with impaired TLR2 function. 21239529 2011
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE Increased mast cell IL-6 production in response to combined TLR2 and NLR activation could play a role in the protection against bacterial infection, but potentially exacerbate inflammation-dependent conditions. 20861644 2011
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE Our study indicated that TLR2 activation by infectious bacterial PGN played an important role in breast cancer cell invasiveness and illustrated a new link between infectious bacteria and the cancer cells, suggesting the importance of antibiotic therapy to treat cancer with bacterial infection. 20520770 2010
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE Our findings demonstrate that during bacterial infection in vivo, newborns selectively and coordinately amplify the TLR2-MyD88 pathway in G+ bacterial infection and the TLR4/MD2/MyD88 pathway in G- bacterial infection, suggesting key roles for innate immune pathway in neonatal responses to bacterial infection. 20805788 2010
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE MyD88 adapter-like (Mal), also termed TIRAP, is involved in bridging MyD88 to the receptor complex for TLR-2 and TLR4 signaling in response to bacterial infection. 19592497 2009
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 AlteredExpression group BEFREE Our study thus provides novel insights into the regulation of TLR2 expression in mixed bacterial infections. 18664270 2008
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation group BEFREE These results have indicated that there is a strong significant relationship between susceptibility to recurrent bacterial infections and Arg753Gln polymorphism of the TLR-2 gene. 17554618 2007
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation group LHGDN Arg753Gln polymorphism of the human toll-like receptor-2 gene in children with recurrent febrile infections. 17554618 2007
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 AlteredExpression group BEFREE TLR2 and TLR4 expression during bacterial infections. 17100621 2006
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group BEFREE Thus, Ca(2+) participates as a second messenger in TLR2-dependent signaling and provides another target to modulate proinflammatory responses to bacterial infection. 16818794 2006
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation group BEFREE Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are associated with bacterial infections, we therefore studied these polymorphisms in osteomyelitis patients. 16487238 2006
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group LHGDN Thus, Ca(2+) participates as a second messenger in TLR2-dependent signaling and provides another target to modulate proinflammatory responses to bacterial infection. 16818794 2006
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 Biomarker group LHGDN TLR2 and TLR4 expression during bacterial infections. 17100621 2006
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 AlteredExpression group LHGDN Thus, our study provides new insights into the role of TGF-beta signaling in positively regulating host defense response by tightly controlling the expression level of TLR2 during bacterial infections and may lead to new therapeutic strategies for modulating host defense and inflammatory response. 16754688 2006
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 AlteredExpression group BEFREE Thus, our study provides new insights into the role of TGF-beta signaling in positively regulating host defense response by tightly controlling the expression level of TLR2 during bacterial infections and may lead to new therapeutic strategies for modulating host defense and inflammatory response. 16754688 2006