Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Neither the BD-associated genetic risk locus within the HLA-B/MICA region nor being on immunosuppressive medications explained the differences between patients and controls. 27283393 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE We found that the HLA-B*51 allele and the rs76546355/rs116799036 MHC SNP are independent genetic risk factors for BD in Iranian, and that positivity for the rs76546355/rs116799036 risk allele, but not for B*51, does correlate with specific demographic characteristics or clinical manifestations in BD patients. 25889189 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker disease CTD_human Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. 20622879 2010
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 Biomarker disease BEFREE The alterations in the nature and affinity of HLA-B*51·peptide complexes probably affect T-cell and natural killer cell recognition, providing a sound basis for the joint association of ERAP1 and HLA-B*51 with BD. 28446606 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE The repeated RPE analysis after separating HLA-B alleles carrying B51-KIR binding sequence as distinct alleles within a broad-type allele group revealed B*2702 allele as the only allele showing an association with BD after the deletion of B*51. 12209364 2002
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE These results suggest the possibility of a primary association of Behcet disease with MICA rather than HLA-B. 9037047 1997
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE In the current study of Behçet disease (BD), nonsynonymous variants (NSVs) identified by deep exonic resequencing of 10 genes found by GWAS (IL10, IL23R, CCR1, STAT4, KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, and ERAP1) and 11 genes selected for their role in innate immunity (IL1B, IL1R1, IL1RN, NLRP3, MEFV, TNFRSF1A, PSTPIP1, CASP1, PYCARD, NOD2, and TLR4) were evaluated for BD association. 23633568 2013
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE The significant increase of HLA-A*2602 and B*3901 in the patient group without HLA-B*51 suggests that these two alleles might also have some secondary influence on the onset of BD. 16671946 2006
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE Thus, HLA-B*51 and HLA-Cw*16 seem to confer susceptibility to BD in this patients. 18627572 2008
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE The strong LD patterns between HLA-B and DR antigens in BD suggest that the susceptibility gene to BD could reside between the these two antigens. 9575677 1998
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE These results suggest that the pathogenic gene of BD is HLA-B51 itself and not other genes located in the vicinity of HLA-B. 11053265 2000
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Association of MICA gene and HLA-B*5101 with Behçet's disease in Greece. 10440244 1999
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE In this study, HLA-B*5101 gene from 37 individuals including Japanese, Turkish, Jordanian and Iranian patients and healthy controls were fully sequenced to further clarify the B*5101 gene in association with BD. 18700875 2008
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE Along with human leukocyte antigen gene encoding B*51 (HLA-B*51) and areas including the major histocompatibility complex class I, genome-wide association studies have recognized numerous other BD susceptibility genes including those encoding interleukin (IL)-10, IL-12 receptor β 2 (IL-12RB2), IL-23 receptor (IL-23R), C-C chemokine receptor 1 gene, signal transducer and activator of transcription 4 (STAT4), endoplasmic reticulum aminopeptidase (ERAP1), and genes encoding killer cell lectin-like receptor family members (KLRC4-KLRK1). 30341905 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Since the identification of HLA-B*5101 (and more recently of MICA) as a susceptibility locus for BD, the identification of additional genetic locus/loci, whether inside, or perhaps more importantly outside the MHC has clearly stalled. 19684014 2010
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease GWASDB Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. 20622878 2010
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26. 20875797 2010
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Behçet's disease. 7591872 1995
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behçet's disease was estimated to be only 19%. 12723980 2003
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE The evaluation of the IL-2 gene polymorphism (p=0.0065) and IL-10 gene polymorphism (p=0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution. 26654556 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE The alterations in the nature and affinity of HLA-B*51·peptide complexes probably affect T-cell and natural killer cell recognition, providing a sound basis for the joint association of ERAP1 and HLA-B*51 with BD. 28446606 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Both HLA-B*51 and MICA*009 are strongly associated with BD in a pure Caucasian BD patient group, and the two alleles are in linkage disequilibrium. 16101830 2005
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Our findings suggest that gene-gene interactions between HLA-B*51 and ERAP1 variants is important for BD development, however, ERAP1 variants which interact with HLA-B*51 may differ among disease phenotypes or populations. 30514861 2018
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 Biomarker disease BEFREE Therefore, although they were not statistically significant, our data were consistent with an association between ERAP1 and BD as well as with an epistatic interaction between ERAP1 and HLA-B in the Spanish population. 25019531 2014