Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.080 AlteredExpression disease BEFREE We observed important increases in the expression of interleukin-8 (IL-8) ( approximately 700-fold), monocyte chemoattractant protein 1 ( approximately 65-fold), interferon-gamma ( approximately 71-fold), and IL-12 ( approximately 69-fold) messenger RNA in BD lesions compared with normal skin. 15248229 2004
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE We observed important increases in the expression of interleukin-8 (IL-8) ( approximately 700-fold), monocyte chemoattractant protein 1 ( approximately 65-fold), interferon-gamma ( approximately 71-fold), and IL-12 ( approximately 69-fold) messenger RNA in BD lesions compared with normal skin. 15248229 2004
Entrez Id: 51284
Gene Symbol: TLR7
TLR7
0.030 GeneticVariation disease BEFREE We investigated whether polymorphisms of Toll-like receptor 7 (TLR7) are associated with BD by analyzing the frequency of eight single nucleotide polymorphisms (SNPs) within 200 Japanese BD patients and 102 randomized controls. 21167247 2011
Entrez Id: 10942
Gene Symbol: PRSS21
PRSS21
0.010 AlteredExpression disease BEFREE We investigated the sublethal effect of B. dendrobatidis infection on a susceptible host, Litoria aurea to test (1) whether the infection load, metabolic activity, body fat and gonad size differed in L. aurea at either 24 °C or 12 °C ambient temperatures and (2) whether previous Bd infection caused long-term changes to body fat and gonad size. 30643160 2019
Entrez Id: 100289462
Gene Symbol: DEFB4B
DEFB4B
0.010 GeneticVariation disease BEFREE We investigated the relationship between copy number variation (CNV) of DEFB4 and BD. 21385545 2011
Entrez Id: 140596
Gene Symbol: DEFB104A
DEFB104A
0.010 GeneticVariation disease BEFREE We investigated the relationship between copy number variation (CNV) of DEFB4 and BD. 21385545 2011
Entrez Id: 1673
Gene Symbol: DEFB4A
DEFB4A
0.010 GeneticVariation disease BEFREE We investigated the relationship between copy number variation (CNV) of DEFB4 and BD. 21385545 2011
Entrez Id: 503618
Gene Symbol: DEFB104B
DEFB104B
0.010 GeneticVariation disease BEFREE We investigated the relationship between copy number variation (CNV) of DEFB4 and BD. 21385545 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.030 GeneticVariation disease BEFREE We investigated the distribution of MDR1 C3435T polymorphism in 69 patients from the Iranian Azeri Turks group with BD and 92 ethnically sex-matched healthy controls, via the polymerase chain reaction-restriction fragment length polymorphism technique. 24898446 2014
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.020 GeneticVariation disease BEFREE We investigated the distribution of MDR1 C3435T polymorphism in 69 patients from the Iranian Azeri Turks group with BD and 92 ethnically sex-matched healthy controls, via the polymerase chain reaction-restriction fragment length polymorphism technique. 24898446 2014
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.040 AlteredExpression disease BEFREE We investigated MBL2 gene polymorphisms and serum MBL levels in BD patients and controls. 19796526 2010
Entrez Id: 27178
Gene Symbol: IL37
IL37
0.060 Biomarker disease BEFREE We investigate TSLP and IL-33 in Behçet disease (BD) and we prove the effect of the anti-inflammatory cytokine IL-37 in BD skin lesions on TSLP production. 29631029 2018
Entrez Id: 337867
Gene Symbol: UBAC2
UBAC2
0.340 GeneticVariation disease BEFREE We identified genetic associations between Behçet's disease and single-nucleotide polymorphisms (SNPs) in KIAA1529, CPVL, LOC100129342, UBASH3B, and UBAC2 (odds ratio = 2.04, 2.26, 1.84, 1.71, and 1.61, respectively; P value = 4.2 x 10-5, 1.0 x 10-4, 3.0 x 10-4, 1.5 x 10-3, and 5.8 x 10-3, respectively). 19442274 2009
Entrez Id: 84959
Gene Symbol: UBASH3B
UBASH3B
0.030 GeneticVariation disease BEFREE We identified genetic associations between Behçet's disease and single-nucleotide polymorphisms (SNPs) in KIAA1529, CPVL, LOC100129342, UBASH3B, and UBAC2 (odds ratio = 2.04, 2.26, 1.84, 1.71, and 1.61, respectively; P value = 4.2 x 10-5, 1.0 x 10-4, 3.0 x 10-4, 1.5 x 10-3, and 5.8 x 10-3, respectively). 19442274 2009
Entrez Id: 54504
Gene Symbol: CPVL
CPVL
0.020 GeneticVariation disease BEFREE We identified genetic associations between Behçet's disease and single-nucleotide polymorphisms (SNPs) in KIAA1529, CPVL, LOC100129342, UBASH3B, and UBAC2 (odds ratio = 2.04, 2.26, 1.84, 1.71, and 1.61, respectively; P value = 4.2 x 10-5, 1.0 x 10-4, 3.0 x 10-4, 1.5 x 10-3, and 5.8 x 10-3, respectively). 19442274 2009
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.010 Biomarker disease BEFREE We have previously described altered subcellular distribution of DISC1 and an aberrant microtubule organization in olfactory neuronal precursors (ONP) obtained from schizophrenia (SCZ) and bipolar disorder (BD) patients. 28927861 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.380 GeneticVariation disease BEFREE We have investigated the frequency of the R/G 241 and K/E 469 ICAM-1 gene polymorphisms in 83 patients with BD disease and 103 healthy controls, all of Palestinian and Jordanian descent, and demonstrated an association between BD and the ICAM-1 E469 allele (Pc = 0.046, OR = 2.1). 10792421 2000
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.090 GeneticVariation disease BEFREE We genotyped 80 patients with BD and 105 healthy controls for interleukin (IL)-1 alpha (T/C -889), IL-1 beta (C/T -511, T/C +3962), IL-1R (C/T pst11970), IL-1RA (T/C mspa111100), IL-2 (T/G -330), IL-12 (C/A -1188), interferon (IFN)-gamma (A/T UTR 5644), and TNF-alpha (G/A -238) polymorphisms. 17211678 2007
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
0.050 Biomarker disease BEFREE We genotyped 80 patients with BD and 105 healthy controls for interleukin (IL)-1 alpha (T/C -889), IL-1 beta (C/T -511, T/C +3962), IL-1R (C/T pst11970), IL-1RA (T/C mspa111100), IL-2 (T/G -330), IL-12 (C/A -1188), interferon (IFN)-gamma (A/T UTR 5644), and TNF-alpha (G/A -238) polymorphisms. 17211678 2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation disease BEFREE We genotyped 80 patients with BD and 105 healthy controls for interleukin (IL)-1 alpha (T/C -889), IL-1 beta (C/T -511, T/C +3962), IL-1R (C/T pst11970), IL-1RA (T/C mspa111100), IL-2 (T/G -330), IL-12 (C/A -1188), interferon (IFN)-gamma (A/T UTR 5644), and TNF-alpha (G/A -238) polymorphisms. 17211678 2007
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 AlteredExpression disease BEFREE We found that the monocytes of active BD patients showed higher expressions of TLR2 and TLR4 than those of controls, and serum 25(OH)D levels tended to be lower in active BD. 18411217 2008
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.080 AlteredExpression disease BEFREE We found that the monocytes of active BD patients showed higher expressions of TLR2 and TLR4 than those of controls, and serum 25(OH)D levels tended to be lower in active BD. 18411217 2008
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE We found that the HLA-B*51 allele and the rs76546355/rs116799036 MHC SNP are independent genetic risk factors for BD in Iranian, and that positivity for the rs76546355/rs116799036 risk allele, but not for B*51, does correlate with specific demographic characteristics or clinical manifestations in BD patients. 25889189 2015
Entrez Id: 100507436
Gene Symbol: MICA
MICA
0.200 GeneticVariation disease BEFREE We found that HLA-B*51 (P = 4.11 × 10(-41), OR [95% CI] = 4.63[3.66-5.85]) and B*15 confer risk for BD (P = 2.83 × 10(-2), OR [95% CI] = 1.75[1.08-2.84]) in Iranian, and in B*51 negative individuals, only the B*15 allele is significantly associated with BD (P = 2.51 × 10(-3), OR [95% CI] = 2.40[1.37-4.20]). rs76546355, formerly known as rs116799036, located between HLA-B and MICA (MHC class I polypeptide-related sequence A), demonstrated the same level of association with BD as HLA-B*51 (P adj = 1.78 × 10(-46), OR [95% CI] = 5.46[4.21-7.09], and P adj = 8.34 × 10(-48), OR [95% CI] = 5.44[4.20-7.05], respectively) in the HLA-B allelotyped subset, while rs2848713 was less associated (P adj = 7.14 × 10(-35), OR [95% CI] = 3.73[2.97-4.69]) and rs9260997 was not associated (P adj = 1.00 × 10(-1)). 25889189 2015
Entrez Id: 7412
Gene Symbol: VCAM1
VCAM1
0.010 Biomarker disease BEFREE We found similar cellular infiltration patterns in response to needle prick in BD patients and controls between 0 and 8 h. Further development of this immune response was limited in skin of normal control subjects, with stable or decreased inflammatory mediators observed at 48 h. In contrast, in BD-derived skin specimens, increased influxes of mature dendritic cells, monocytes, and lymphocytes, including T regulatory cells, were noted by 48 h. Similarly, increases in cytokines (IFN-gamma, IL-12 p40, IL-15), chemokines (MIP3-alpha, IP-10, Mig, and iTac), and adhesion molecules (ICAM-1, VCAM-1) were noted at 48 h in the skin of BD patients with SPR(+) but not in the skin of normal controls. 17056573 2006