Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 AlteredExpression disease BEFREE The same difference was observed in IL-10 levels in culture supernatant after T. Baseline TLR4 expression was significantly higher in BD patients compared to healthy donors (HC). 27467286 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Our results confirm HLA-B*51 as a primary-association marker in predisposition to BD and suggest additional independent signals within the class I region, specifically in the genes HLA-A and HLA-B. 27548383 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE We found that the HLA-B*51 allele and the rs76546355/rs116799036 MHC SNP are independent genetic risk factors for BD in Iranian, and that positivity for the rs76546355/rs116799036 risk allele, but not for B*51, does correlate with specific demographic characteristics or clinical manifestations in BD patients. 25889189 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE Using a state-of-the-art imputation method to analyse the major histocompatibility complex (MHC) region, Ombrello and colleagues narrowed down the association between human leukocyte antigen (HLA)-B51 and Behçet's disease to a model of five amino acids of the HLA-B molecule involved in the binding of the antigen, the interactions with receptors on CD8 T cells and natural killer cells, and the signal peptide of HLA-B, suggesting a crucial role of the cellular cytotoxicity on this disease. 25405820 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD. 26213801 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Although we were not able to formally replicate the association with IL10 and IL23R-IL12RB2, we do report that BD in Iran is strongly associated with HLA-B*51, MICA-A6, and the three HLA-linked SNPs (odds ratio (OR) = 3.38, P = 6.21 × 10(-14); OR = 2.08, P = 1.58 × 10(-13); and OR = 1.67-4.05, P = 1.45 × 10(-04) to 4.79 × 10(-34), respectively). 25940109 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker disease BEFREE We tested 14 single-nucleotide polymorphisms (SNPs) in 13 genomic loci (excluding the major histocompatibility complex [MHC], IL10, and IL23R-IL12RB2, which have already been associated with BD in Iranians) for allelic and genotypic associations with BD in 973 patients and 828 controls from Iran and performed meta-analyses of the significantly associated markers. 26097239 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 SusceptibilityMutation disease ORPHANET Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population. 26015771 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE In this Perspectives article, we describe how Behçet disease and several clinically distinct spondyloarthropathies-all associated with MHC class I (MHC-I) alleles such as HLA-B(*)51, HLA-C(*)0602 and HLA-B(*)27 and epistatic ERAP-1 interactions-have a shared immunopathogenetic basis. 26526644 2015
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 SusceptibilityMutation disease ORPHANET Brief report: association of CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 With Behçet's disease in Iranians. 26097239 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE Non-HLA genetic associations such as endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R) and IL10 variations suggest that BD shares susceptibility genes and inflammatory pathways with spondyloarthritis. 26068404 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Moreover, we need to determine allele-specific effects of ERAP1 variants in the context of HLA-B*51 and HLA-Cw*6, which are associated with Behçet's disease and psoriasis, respectively. 26002027 2015
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 Biomarker disease BEFREE This study reinforces the notion that CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 are bona fide susceptibility genes for BD, in addition to the MHC, IL10, and IL23R-IL12RB2 loci. 26097239 2015
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 GeneticVariation disease BEFREE Genetic variants and haplotypes of ERAP1 are associated with AS, psoriasis, and Behçet's disease in people of varying ancestries. 26002026 2015
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 Biomarker disease BEFREE Non-HLA genetic associations such as endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R) and IL10 variations suggest that BD shares susceptibility genes and inflammatory pathways with spondyloarthritis. 26068404 2015
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 GeneticVariation disease BEFREE In this Perspectives article, we describe how Behçet disease and several clinically distinct spondyloarthropathies-all associated with MHC class I (MHC-I) alleles such as HLA-B(*)51, HLA-C(*)0602 and HLA-B(*)27 and epistatic ERAP-1 interactions-have a shared immunopathogenetic basis. 26526644 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Behçet's disease (BD), a multi-organ inflammatory disorder, is associated with the presence of the human leukocyte antigen (HLA) HLA-B*51 allele in many ethnic groups. 26331842 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE HLA-B*15, -B*27, -B*57, and -A*26 are independent risk factors for Behçet's disease, while HLA-B*49 and -A*03 are independent class I alleles that are protective for Behçet's disease. 26347074 2015
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 GeneticVariation disease BEFREE Moreover, we need to determine allele-specific effects of ERAP1 variants in the context of HLA-B*51 and HLA-Cw*6, which are associated with Behçet's disease and psoriasis, respectively. 26002027 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker disease BEFREE Although we were not able to formally replicate the association with IL10 and IL23R-IL12RB2, we do report that BD in Iran is strongly associated with HLA-B*51, MICA-A6, and the three HLA-linked SNPs (odds ratio (OR) = 3.38, P = 6.21 × 10(-14); OR = 2.08, P = 1.58 × 10(-13); and OR = 1.67-4.05, P = 1.45 × 10(-04) to 4.79 × 10(-34), respectively). 25940109 2015
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 GeneticVariation disease BEFREE In the present study, we investigated the association of ERAP1 gene polymorphisms with BD in a Chinese Han population. 26393469 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population. 26015771 2015
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 Biomarker disease BEFREE Therefore, although they were not statistically significant, our data were consistent with an association between ERAP1 and BD as well as with an epistatic interaction between ERAP1 and HLA-B in the Spanish population. 25019531 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE Thus, this study aimed to investigate the associations between IL-6 and IL-10 promoter single-nucleotide polymorphisms (SNPs) and the susceptibility to BD and their implication on plasma levels. 24703990 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker disease BEFREE IL10 may be the susceptibility gene for BD in Chinese Han population. 24269690 2014