| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | AlteredExpression | disease | BEFREE | MiR-155 and TNF-α expression was significantly increased, whilst CTLA-4 expression was significantly decreased in the PBMCs of BD patients. | 30366049 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | The CTLA-4 gene could be considered as a susceptibility and a disease-modifying gene to BD in Egyptian population that needs further confirmatory studies on larger cohorts. | 24991555 | 2014 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Our study failed to provide evidence for the genetic association between CTLA-4 +49A/G and -318C/T polymorphisms with Behçet's disease based on currently available evidence from literature. | 23010350 | 2013 | ||||
|
0.090 | Biomarker | disease | BEFREE | Although our understanding of the role of the CTLA4 gene and its protein product in BD is incomplete, these results suggest that single nucleotide polymorphisms of the promoter and exon regions in the CTLA4 gene are candidates that predispose to BD and that sCTLA4 may be related to the immunological abnormalities and disease expressions associated with BD. | 19563524 | 2009 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | The association of polymorphisms in CTLA-4 and CD28 with some immune vasculitides, such as systemic lupus erythematosus (SLE) and Behçet's disease has been reported. | 19284445 | 2009 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | This study and a meta-analysis failed to demonstrate any association between the tested CTLA-4 polymorphisms and BD. | 19570770 | 2009 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Moreover, there was no association with SNP in CTLA-4 and disease manifestations in BD or outcome in patients with intermediate uveitis. | 18498289 | 2008 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Genotype and allele frequencies of the CTLA-4-318C/T polymorphism between the BD and healthy control groups were not significantly different (12.2% vs. 10.6%, OR = 1.170, 95% CI = 0.570-2.402, P = 0.713). | 17284227 | 2007 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | It was shown that the distribution of the CTLA-4 exon 1 49A/G allele and genotype frequencies did not differ between patients with BD and healthy controls. | 16045690 | 2005 |