Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE IL-8 could act as a novel target for the treatment of BD theoretically and probably play a key role in disease recovery. 31695669 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE Upon stimulation with SAA, monocytes obtained from both HC and BD groups released large amounts of IL-8, IL-6, TNF-α, IL-1β and IFN-α. 30385329 2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation disease BEFREE We demonstrated that the frequencies of IL-8 haplotypes were significantly different with BD patients than control group. 27101127 2016
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation disease BEFREE The single nucleotide polymorphisms of the IL-6 and IL-8 receptor genes and the TNF-alpha gene analysed here do not appear to be associated with Behçet's disease. 19026125 2009
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE The aim of this study was to develop tools as reliable as IL-8 levels in defining BD severity. 19187295 2009
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation disease BEFREE Polymorphisms in interleukin-10, IL-8 and CD28 genes were also associated with Behçet's disease. 18281862 2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation disease LHGDN In conclusion, we found a significant difference in the distribution of IL-8 gene haplotypes between patients with BD and healthy controls. 17257314 2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE In our previous studies, we found higher synovial fluid (SF) levels of angiogenic ELR(+) CXC chemokines such as CXCL1, CXCL5, CXCL6 and CXCL8, which play an important role in neutrophil migration and angiogenesis, and more abundant synovial CXCR2 chemokine receptor expression in patients with rheumatoid arthritis (RA) than those with Behçet's disease (BD), familial Mediterranean fever and osteoarthritis (OA). 17265155 2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation disease BEFREE These results suggest that the genetic polymorphisms of proinflammatory chemokine IL-8 can contribute to the pathogenesis of BD. 17257314 2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease LHGDN Serum interleukin-8 as a serologic marker of activity in Behçet's disease. 16101867 2005
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation disease BEFREE These results suggest that the IL-8 gene -353 A/G, +1530 T/C, and +3331 A/G and the CXCR2 gene +785 C/T and +1208 T/C polymorphisms have no role in the increased expression of IL-8 in BD. 15630732 2005
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression disease BEFREE We observed important increases in the expression of interleukin-8 (IL-8) ( approximately 700-fold), monocyte chemoattractant protein 1 ( approximately 65-fold), interferon-gamma ( approximately 71-fold), and IL-12 ( approximately 69-fold) messenger RNA in BD lesions compared with normal skin. 15248229 2004
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease BEFREE Our results suggest that the cellular source of IL-8 is diverse in BD with a possible major contribution by lymphocytes. 10812500 2000
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker disease CTD_human Neutrophil adhesion to endothelial cells and factors affecting adhesion in patients with Behçet's disease. 8712863 1996