The associations between the two DNA polymorphisms that are closely linked to the POMC gene and both schizophrenia and bipolar disorder were investigated.
Plasma cholinesterase activity was found to be significantly lower than normal in bipolar (BP), unipolar (UP), other affective disorder (OA) and well subjects belonging to manic-depressive families.
Cholinesterase activities were measured in plasma (ChE) and in intact erythrocytes (AChE) in patients suffering from manic-depressive illness, their first degree relatives who were well, and unrelated normal volunteers.
A genetic linkage has been demonstrated between manic depression and coagulation factor IX at Xq27 with a TaqI polymorphism at the F9 locus in DNA samples from peripheral leucocytes of manic depressive probands and relatives in 10 informative families.
We found no evidence for linkage to these markers in any of the three families.In contrast, Gerhard et al. found linkage between manic depression and HRAS1 in a single large Amish kindred.
We found no evidence for linkage to these markers in any of the three families.In contrast, Gerhard et al. found linkage between manic depression and HRAS1 in a single large Amish kindred.
We found no evidence for linkage to these markers in any of the three families.In contrast, Gerhard et al. found linkage between manic depression and HRAS1 in a single large Amish kindred.
X-linked manic depression and other psychiatric disorders have been mapped to this region, and thus GABRA3 is a potential candidate gene for these disorders.
Linkage analyses of bipolar disorder with the chromosome 11p15 DNA markers HRAS1 and INS, and the chromosome Xq28 markers for color blindness and G6PD have been reported.
The tyrosine hydroxylase gene encodes the rate-limiting enzyme in the synthesis of catecholamines and might be a candidate for causing the manic-depressive phenotype.
Linkage analyses of bipolar disorder with the chromosome 11p15 DNA markers HRAS1 and INS, and the chromosome Xq28 markers for color blindness and G6PD have been reported.
Linkage analyses of bipolar disorder with the chromosome 11p15 DNA markers HRAS1 and INS, and the chromosome Xq28 markers for color blindness and G6PD have been reported.
Linkage analyses of bipolar disorder with the chromosome 11p15 DNA markers HRAS1 and INS, and the chromosome Xq28 markers for color blindness and G6PD have been reported.