Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 GeneticVariation disease BEFREE Lastly, we examined the associations of the GAD1 gene and BD in two additional independent datasets with a few thousand samples for replication. 28710909 2017
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 AlteredExpression disease BEFREE Several genes within this GAD1 regulatory network show diagnosis- and sector-specific expression changes within the circuitry of the hippocampus, influencing abnormal GAD1 expression in schizophrenia and bipolar disorder. 25738424 2015
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease PSYGENET Several genes within this GAD1 regulatory network show diagnosis- and sector-specific expression changes within the circuitry of the hippocampus, influencing abnormal GAD1 expression in schizophrenia and bipolar disorder. 25738424 2015
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease PSYGENET Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons. 25364290 2014
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 AlteredExpression disease BEFREE Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons. 25364290 2014
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease BEFREE The copy number intensities examined using both microarrays and quantitative real-time polymerase chain reaction for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. 22309971 2012
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease PSYGENET The copy number intensities examined using both microarrays and quantitative real-time polymerase chain reaction for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder. 22309971 2012
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease BEFREE In schizophrenia and bipolar disorder, a network of genes involved in the regulation of GAD₆₇, a marker for the functional differentiation of GABA cells, show pronounced changes in expression and include kainate receptor subunits, TGFβ and Wnt signaling pathways, epigenetic factors and transcription factors. 21184762 2011
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease PSYGENET The nature of these changes is quite different in schizophrenia and bipolar disorder, suggesting that a common cell phenotype (in this case, decreased GAD₆₇ expression) may involve two fundamentally different molecular endophenotypes and reflect unique susceptibility genes involved in the respective disorders. 21184762 2011
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease PSYGENET This molecular remodeling may contribute to the induction of reelin (RELN) and GAD(67) (GAD1) promoter demethylation, and may reverse the downregulation of various GABAergic mRNAs and proteins detected in the telencephalon of patients with schizophrenia or bipolar disorders. 22122643 2009
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease BEFREE We found that the density of GAD67+ neurons in layers 2-5 of the prefrontal cortex was decreased by 27-36% in both schizophrenia and bipolar disorder. 18534564 2008
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 AlteredExpression disease BEFREE This is the first demonstration that there is more DNA fragmentation in cells showing no detectable GAD67 mRNA in patients with bipolar disorder than in schizophrenics or controls. 17442540 2007
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease BEFREE The DNMT1 increase and the GAD67 decrease in BA9 interneurons are significant features of SZ and bipolar disorder with psychosis. 15684088 2005
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease CTD_human GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. 15560956 2005
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 Biomarker disease BEFREE Previous studies suggest linkage between D2S326 near GAD1 and BPAD. 15806582 2005
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
0.600 AlteredExpression disease BEFREE A research strategy directed toward identifying specific neurochemical markers operative in the etiopathology of psychotic disorders lead to the identification of a downregulation (30-50%) of Reln and glutamic acid decarboxylase 67(GAD67) expression in prefrontal cortex and other brain areas of schizoprenia and bipolar disorder patients with psychosis. 11059795 2000